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HIV-1 protease

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Structure of HIV Protease (PDB code 2nmz)

3D Structures of HIV-1 protease

  1. Virus protease

Additional Resources

For additional information, see: Human Immunodeficiency Virus

References

  1. Tie Y, Kovalevsky AY, Boross P, Wang YF, Ghosh AK, Tozser J, Harrison RW, Weber IT. Atomic resolution crystal structures of HIV-1 protease and mutants V82A and I84V with saquinavir. Proteins. 2007 Apr 1;67(1):232-42. PMID:17243183 doi:10.1002/prot.21304
  2. Maschera B, Darby G, Palu G, Wright LL, Tisdale M, Myers R, Blair ED, Furfine ES. Human immunodeficiency virus. Mutations in the viral protease that confer resistance to saquinavir increase the dissociation rate constant of the protease-saquinavir complex. J Biol Chem. 1996 Dec 27;271(52):33231-5. PMID:8969180
  3. Naicker P, Achilonu I, Fanucchi S, Fernandes M, Ibrahim MA, Dirr HW, Soliman ME, Sayed Y. Structural insights into the South African HIV-1 subtype C protease: impact of hinge region dynamics and flap flexibility in drug resistance. J Biomol Struct Dyn. 2012 Nov 12. PMID:23140382 doi:10.1080/07391102.2012.736774

Proteopedia Page Contributors and Editors (what is this?)

Eran Hodis, David Canner, Eric Martz, Ann Taylor, Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman

DOI: http://dx.doi.org/10.14576/315240.1864715 (?)
Citation: Hodis E, Sussman J L, Martz E, Canner D, Harel M, Prilusky J, Berchansky A, 2013, "HIV-1 protease", Proteopedia, DOI: http://dx.doi.org/10.14576/315240.1864715
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