User:David Solfiell/sandbox 1
From Proteopedia
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| Cholera toxin 1xtc | |||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Cholera toxin (CTX) from the bacterium Vibrio cholerae is an oligomeric complex of an enzymatic subunit (chain A) and 5 copies of chain B which bind to the cell surface. The enzymatic subunit has a globular domain (CTA1) and a long helical domain (CTA2). Once the CTX binds to the cell surface, it is internalized, and its CTA1 domain binds to ADP-ribosylation factor 6 (Arf6) enabling its catalytic activity. The images at the left and at the right correspond to the crystal structure of cholera toxin (1xtc).
3D Structures of Cholera toxin
Updated November 2011
CTX
1xtc - CTX
CTX A subunit
2a5d, 2a5g – CTX A subunit+hArf6+GTP – human
2a5f - CTX A subunit+hArf6+GTP+NAD
1s5b, 1s5c, 1s5d, 1s5e, 1s5f - CTX A subunit (mutant)
CTX B subunits
1fgb - CTX B subunits
1g8z , 1chp, 1chq - CTX B subunits (mutant)
1rcv, 1rd9, 1rdp, 1rf2, 1pzi, 1pzj, 1pzk, 1efi, 1eef, 1djr, 1eei – CTX B subunits+ galactoside derivatives
1llr, 1jqy, 1jr0, 1fd7, 1md2 - CTX B subunits+BMSC derivatives
1eef - CTX B subunits+PEPG
3chb, 2chb - CTX B subunits+pentasaccharide
1ct1 - CTX B subunits (mutant)+pentasaccharide
3efx – CTX B/heat-labile enterotoxin B chain
1tet – CTX peptide 3+FAB light and heavy chains - mouse
