User:Bhaskar Ganguly/MyBo HyPo

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The MyBo HyPo Project

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Welcome to the Mycobacterium bovis' Hypothetical Protein (MyBo HyPo) Project.

The MyBo HyPo Project aims towards a computational characterization of all hypothetical proteins of M. bovis. A Hypothetical Protein (HP) is one that is known to exist only on the basis of a corresponding gene but without any function assigned to it. Characterization of HPs of a pathogen has a potential for unraveling hitherto unknown drug and vaccine targets. M. bovis is an important veterinary pathogen of zoonotic significance, responsible for causing nearly 3% of all human cases of tuberculosis in the developing world.

As for now, computationally-derived models of 14 M. bovis HP UniRefs, obtained at a 90% sequence identity cut-off from all HPs of M. bovis in the UniProt Database, are being included. These models shall be updated as and when models of better quality become available. We also plan to add models of M. bovis HP sequences from other databases over the coming periods of time. - Bhaskar Ganguly, Ph.D.; Sunil Kr. Rastogi, Ph.D.

(Note: It may take a while for the models to load completely. Your web browser must be configured to run Java for visualization of the interactive protein models. Right click on a model to download it and for access to more options. Left click and drag a model to rotate view.)

Contents 1 M. bovis HP A0A083W064 1.1 UniProt Description 1.2 Sequence 1.3 Length 1.4 Predicted Localization 1.5 Putative Function 2 M. bovis HP A0A083W0M1 2.1 UniProt Description 2.2 Sequence 2.3 Length 2.4 Predicted Localization 2.5 Putative Function 3 M. bovis HP A0A0C7DGT6 3.1 UniProt Description 3.2 Sequence 3.3 Length 3.4 Predicted Localization 3.5 Putative Function 4 M. bovis HP A0A083VPW0 4.1 UniProt Description 4.2 Sequence 4.3 Length 4.4 Predicted Localization 4.5 Putative Function 5 M. bovis HP A0A083VTH6 5.1 UniProt Description 5.2 Sequence 5.3 Length 5.4 Predicted Localization 5.5 Putative Function 6 M. bovis HP A0A083VUK1 6.1 UniProt Description 6.2 Sequence 6.3 Length 6.4 Predicted Localization 6.5 Putative Function 7 M. bovis HP A0A083W378 7.1 UniProt Description 7.2 Sequence 7.3 Length 7.4 Predicted Localization 7.5 Putative Function 8 M. bovis HP A0A083WED4 8.1 UniProt Description 8.2 Sequence 8.3 Length 8.4 Predicted Localization 8.5 Putative Function 9 M. bovis HP A0A093N4V5 9.1 UniProt Description 9.2 Sequence 9.3 Length 9.4 Predicted Localization 9.5 Putative Function 10 M. bovis HP A0A0C7DM56 10.1 UniProt Description 10.2 Sequence 10.3 Length 10.4 Predicted Localization 10.5 Putative Function 11 M. bovis HP A0A0C7DHL0 11.1 UniProt Description 11.2 Sequence 11.3 Length 11.4 Predicted Localization 11.5 Putative Function 12 M. bovis HP A0A083VPS0 12.1 UniProt Description 12.2 Sequence 12.3 Length 12.4 Predicted Localization 12.5 Putative Function 13 M. bovis HP A0A083VYR3 13.1 UniProt Description 13.2 Sequence 13.3 Length 13.4 Predicted Localization 13.5 Putative Function 14 M. bovis HP A0A083W2L5 14.1 UniProt Description 14.2 Sequence 14.3 Length 14.4 Predicted Localization 14.5 Putative Function

M. bovis HP A0A083W064

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UniProt Description

Hypothetical arginine and alanine rich protein

Sequence

MARQPLEQRVARAAQAALARQRFVSAIDVLLGLGWLAPSHVDQWRQGRVDSLEQVVQANL

SKITAVMAALRRWARDRGLNPSETDYVARTRDRRRLRFSVTGEDAIERAYRTHWVSPELS

ERAVARQSRRPDLVVIMPVNDWSCASCGGSGDLMFLEDAGPLCLDCADLGHLVFLPSGDA

ALTRRAKRASRLSAVVVRWSRARKRYERQGILVEAEALERAENECLADAEVRARRRERDE

ARRANEDLRLQAEFGAAIRTLFPNCPAGRAEAIARHAATRGSGRIGRSAAGRALDPEAVR

LAVAASVRHIDTSFDELLMSGVDRETARHRVGEHVEEVLRDWRATSR

Length

347

Predicted Localization

Cytoplasmic

Putative Function

Arginine decarboxylase

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M. bovis HP A0A083W0M1

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UniProt Description

Conserved hypothetical alanine rich protein

Sequence

MSTFRECRSMFDAAVKSYQSGDLANARAAFGRLTVENPDMSDGWLGLLACGDHHLDTLAG

AHQHSEALYSETRRVGLTDGELSAVVMAPMYLGLRVWSRATIGLAYASALIIADRHDEAA

ATLDDPVITEDTGAAQYRQFVMATLFHKTRSWSNLLKVTEISPPSGATDVRDEVADAVAA

LASTAAASLGQFQFALELAEQVSTTNPRVTADVTLTRAWCLRELGDDDAARVALSATTTG

DAPRTNTTAEQAGSPQPKFRHPYDDGRDLLVARRRPPAGDGWRKAVTKMTFGRVNPEPSA

KREQTDELIQRICAPLADVHKLAFVSAKGGVGKTTMTVLVGNAVARLRGDRVMAVDVDAD

LGDLSARFSERGGPQTNIEHFVSSQHTKRYADVRVHTVMNKDRLEMLGAQNDPRSTYKFG

PEDYGAAMQILETHCNVILLDCGTPVNGPLFSNILNDVTGLVVVASEDVRGVEGALVTLD

WLGAHGFGRLLQHTVVVLNAIQKTRSLVDCGAAENQFRKRVPDFFRIPYDPHLATGLAVD

FSSLKRRTRNAVLDLAGGLAQHYPASRVRPRGEDSWKTWIETMRQVG

Length

587

Predicted Localization

Cytoplasmic

Putative Function

Cell Division Inhibitor MIND

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M. bovis HP A0A0C7DGT6

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UniProt Description

Conserved hypothetical alanine and proline rich protein

Sequence

MADRLNVAERLAEGRPAAEHTQSYVRACHLVGYQHPDLTAYPAQIHDWYGSEDGLDLHAL

DADCAQLRAAASVLMEALRMERSQVAVLAAAWTGSGADAAVHFVQRHCETGNSVVTEVRA

AAQRCESLRDNLWQLVDSKVATAIAIDERALAQRPAWLAAAEALTTEGADRPTAVEVVRQ

QIQPYVDDDVRNDWLTTMRSTTAGVAASYDAVTDQLASAPRAHFEIPDDLGPGRQPSPAS

VPAQPSATAAITPAAALPPPDPVPAVTSRPVTPSDFGSAPGDGSATPAGVGSAGGFGDAG

GTGGLGGFAGLAGLANRIVDAVDSLLGSVAEQLGDPLAADNPPGAVDPFAEDAADNADDG

DDAHPEEAGEAAEPKEATEPDEADEVDDADESVPAERAQDVAEEATLPPVAEPPPPAAPP

VAEPPPPVAAPAPPGAPEPANGPSPEALSEGATPCEIAADELPQAGP

Length

467

Predicted Localization

Cytoplasmic

Putative Function

Undetermined

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M. bovis HP A0A083VPW0

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UniProt Description

Conserved hypothetical alanine rich protein

Sequence

MVAADLPPGRWSAVLVGAWWPAPSAALRAAAQHWATWAMQKQELARNLISQHDLLLRNQG

RTAEDLIGRYLRGAKSEVTKAEKYEIKKGAFNTAADAIDYLRSRLTGIAGEGNKEIDDVL

ASKKPLPEQLAEIQAIQTRCNADAANASRDAVDKVMTAMQEILEAEDIGDDPRTWARANG

FNVDDAPPPRLIRENDLAALTGPGARGGSFGSVEGAGDLASPQSVGAGGFSGSGVQAACS

QPAPRAIGASSRHASAGPVPPAPVVTTPAAATPPVIATGPRWRCPAGRCRRRPSDRAYRL

RRLGNRLRPGW

Length

311

Predicted Localization

Outer Membrane

Putative Function

Rhamnosidase

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M. bovis HP A0A083VTH6

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UniProt Description

Hypothetical alanine and valine rich protein

Sequence

MSPHRAVIEAGPGAIRRLCCGADVVADTAVSAAALAAIDDQVALLDERPVAVDSLWFDAL

RSVAVDHRDGPVVVHPSWWSAARVEVVTAAARTLTRDVVVHPRSWLLRQASSGVSAATVV

VEIAERLVLVAGAEVAAVARRTDAESVAGQVGSVIARMTRGITAVVLIDVPSTVAGAAAL

AAAIAGAVRGTGSSVVEIDGVRLARLARAALPPSDEPADPAARPATRSRVPTLARVAAAG

VALALLAPAAVVRHGATTLQRPPTTLLVEGRVALTIPADWSTQRVVSGPGSARVQVTSPA

DPEVALHVTQSPVPGETLPGTAQRLKRAIDASPAGVFVDFNPSDIRAGRPAVTYREVRAG

HQVRWTILLDGAVRISVGCQSGPGHEDLLREVCAQAVRSVHAVG

Length

404

Predicted Localization

Outer Membrane

Putative Function

Photosystem II protein PsbP

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M. bovis HP A0A083VUK1

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UniProt Description

Hypothetical proline rich protein

Sequence

MFTGIASHAGALGAALVVLIGAAILHDGPAAADPNQDDRFLALLEKKEIPAVANVPRVID

AAHKVCRKLDGGMPVNDIVDGLRNDAYNIDPVMRLYPVRLTTTMTRFISAAVEIYCPNHH

SKMAFAMANFEPGSNEPTHRVAASTRSAVNSGSDLRASVSDMTIMSPGWREPTGAMLASV

LGAVRAGDPLIPNPPPIPVPPPAAQTLIPPPPIVAPPPPRPAPPQQPPPPPPEVEPPAGV

PQSGGAAGSGGAGSGGGGGGDGPVEPSPARPMPPGFIRLAP

Length

281

Predicted Localization

Outer Membrane

Putative Function

Transcriptional activator

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M. bovis HP A0A083W378

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UniProt Description

Conserved hypothetical proline rich protein

Sequence

MATGARPALGLSIGVTNLAAVAADHSITRKPVLTLYRQRPPEVGVPSENPRLDEPGLVIT

DFVDRVGDSVGIVAADGSVYRSEALVADALLALAYTATGGRALPGSVTVTYPAHWGPAAV

AALDSALRRASEWSHGTSSTAQPLSLLPDAAAALYAIRADPGIPARGIVAVCDFGGSGTG

ITLVDAADEYRPVAATVRHQAFSGDLIDQSLLSYVMSELPGTGAFDPAGTSAIGSLTKLR

IECRKAKERLSSSTVTTLTDALGGDIRLTRNELEDTIRDSLDSVGRALEQTLARSGIRTA

ELVAIVSVGGGANIPAVTTTLSGRFCVPVVRTPRPQLTAAFGGALWAARRPGDTSATVLT

AVTSATATAPADAPASVLQPALAWSEADEDSHIGPAPGYTAARPSLSFDHDAHAEPEPKS

PPIPWYRLPAVIITGTTVAVLLVGAAVAIGLSTGDQPTAPGTPQRPGVTTTAAPPPSPAP

ASDGPTTEPAPPVQAPATGGPAPPLQQPLPPPPTTTNTQPAVTTDVITPAPTTPASAPPA

TTQPPATTQPPATTSPSPPPIPPIPPIPEIPQLPPGIPQVPGIGQFSAISGS

Length

592

Predicted Localization

Outer Membrane

Putative Function

Chaperone (DnaK-like)

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M. bovis HP A0A083WED4

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UniProt Description

Alanine and proline rich protein

Sequence

MPTIWTFVRAAAVLVGSSAALLTGGIAHADPAPAPAPAPNIPQQLISSAANAPQILQNLA

TALGATPPLSAPKVAEPAPAAPGITATFPGLTPAAPAAAAAPALTPSIPGVNAPIPGITP

AAPALPVTAPAAAPTIPGVNAPIPGITAPAPAAAAVPASVPGVPSAKVDLPQLPYLPLQV

PQQLSLPADLPALASGVIPAAPIAPTPPAPGAPALPPGPPSLLAALP

Length

227

Predicted Localization

Outer Membrane

Putative Function

snRNP assembly (human gemin 1-like)

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M. bovis HP A0A093N4V5

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UniProt Description

Hypothetical glycine rich protein

Sequence

MAFVDLRYPWCRGDGWISPPVVAVALGWAMRRKPFSRFNEYVGSASNTCWFARALELRTL

LIR

Length

63

Predicted Localization

Outer Membrane

Putative Function

Transcriptional repressor (KorB-like)

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M. bovis HP A0A0C7DM56

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UniProt Description

Alanine and arginine and proline rich protein

Sequence

MMASNQTAAQHSSATLQQAPRSIDDAGGCPLTISPIANSPGDTFAVTPVVEYEPPPRNIP

PCGQSSHAARRPHTPQLARRQPIRPSGRAPAAVTSTAKSPRLRQAGTFADAALRRVLEVI

DRRRPVGQLRPLLAPGLVDSVLAVSRTAAGHQQGAAMLRRIRLTPAGPDTADTAAEVFGT

YSRGDRIHAIACRVEQRPAGNETRWLMVALHIG

Length

213

Predicted Localization

Outer Membrane

Putative Function

Palmitoyl CoA hydrolase

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M. bovis HP A0A0C7DHL0

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UniProt Description

Conserved hypothetical alanine rich protein

Sequence

MAEPLAVDPTGLSAAAAKLAGLVFPQPPAPIAVSGTDSVVAAINKTMPSIESLVSDGLPG

VKAALTRTASNMNAAADVYAKTDQSLGTSLSQYAFGSSGEGLAGVASVGGQPSQATQLLS

TPVSQVTTQLGETAAELAPRVVATVPQLVQLAPHAVQMSQNASPIAQTISQTAQQAAQSA

QGGSGPMPAQLASAEKPATEQAEPVHEVTNDDQGDQGDVQPAEVVAAARDEGAGASPGQQ

PGGGVPAQAMDTGAGARPAASPLAAPVDPSTPAPSTTTTL

Length

280

Predicted Localization

Secreted

Putative Function

ESX-1 secretion-associated protein EspB

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M. bovis HP A0A083VPS0

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UniProt Description

Alanine and proline rich protein

Sequence

MAPLAVDPAALDSAGGAVVAAGAGLGAVISSLTAALAGCAGMAGDDPAGAVFGRSYDGSA

AALVQAMSVARNGLCNLGDGVRMSAHNYSLAEAMSDVAGRAAPLPAPPPSGCVGVGAPPS

AVGGGGGAPKGWGWVAPYIGMIWPNGDSTKLRAAAVAWRSAGTQFALTEIQSTAGPMGVI

RAQQLPEAGLIESAFADAYASTTAVVGQCHQLAAQLDAYAARIDAVHAAVLDLLARICDP

LTGIKEVWEFLTDQDEDEIQRIAHDIAVVVDQFSGEVDALAAEITAVVSHAEAVITAMAD

HAGKQWDRFLHSNPVGVVIDGTGQQLKGFGEEAFGMAKDSWDLGPLRASIDPFGWYRSWE

EMLTGMAPLAGLGGENAPGVVESWKQFGKSLIHWDEWTTNPNEALGKTVFDAATLALPGG

PLSKLGSKGRDILAGVRGLKERLEPTTPHLEPPATPPRPGPQPPRIEPPESGHPAPAPAA

KPAPVPANGPLPHSPTESKPPPVDRPAEPVAPSSASAGQPRVSAATTPGTHVPHGLPQPG

EHVPAQAPPATTLLGGPPVESAPATAHQPQWATTPAAPAAAPHSTPGGVHSTESGPHGRS

LSAHGSEPTHDGASHGSGHGSGSEPPGLHAPHREQQLAMHSNEPAGEGWHRLSDEAVDPQ

YGEPLSRHWDFTDNPADRSRINPVVAQLMEDPNAPFGRDPQGQPYTQERYQERFNSVGPW

GQQYSNFPPNNGAVPGTRIAYTNLEKFLSDYGPQLDRIGGDQGKYLAIMEHGRPASWEQR

ALHVTSLRDPYHAYTIDWLPEGWFIEVSEVAPGCGQPGGSIQVRIFDHQNEMRKVEELIR

RGVLRQ

Length

846

Predicted Localization

Secreted

Putative Function

Tuberculosis necrotizing toxin

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M. bovis HP A0A083VYR3

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UniProt Description

Conserved hypothetical alanine rich protein

Sequence

MAVDLDGVTTVLLPGTGSDNDYVRRAFSAPLRRAGAVLVTPVPHPGRLIDGYRAALDDAA

RDGPVVVGGVSLGAAVAAAWALEHPDRAVAVLAALPAWTGEPELAPAAQAARYTAARLRC

DGLAATTTRMRASSPVWLAEELTRSWRVQWPELPDAMEEAAAYVAPSRAELARLVAPLAV

AAAVDDPIHPLQVAADWVSVAPHAALRTVTLDEIGADAAALGSACLAALAEVSGA

Length

235

Predicted Localization

Secreted

Putative Function

Heme bromoperoxidase

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M. bovis HP A0A083W2L5

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UniProt Description

Glycine rich protein

Sequence

MEEVPTGPPAMGHRACGGQKAAFPTRMNSGVEKMYKNSIAIAIGTLTMAVEFSMVSANAE

PAPPPGQDPHMPNSAMGYCPGGGFGGITGWGYCDGIRYPDGSYWHQVRVPAPFVGTTLTL

SCVIDDGSPVPPLAAPGSCGGGA

Length

143

Predicted Localization

Secreted

Putative Function

Type 2 secretory system protein (major Pseudopilin-like)

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