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Tropomyosin

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Pig tropomyosin (PDB code 1c1g)

3D structures of Tropomyosin

Updated on 25-May-2014

3mtu, 3mud – cTPM alpha-1 – chicken
1ic2 - cTPM alpha-1 (mutant)
3u1a, 3u1c – cTPM α-1 N terminal
3u59 – cTPM β N terminal
2w49, 2w4u – cTnnC+cTnnT+cTnnI+cTPM alpha-1+cActin
2z5h – yTPM alpha-1 N-terminal+C-terminal+GNC4 leucine zipper+TnnT – yeast
2z5i - yTPM alpha-1 N-terminal+C-terminal+GNC4 leucine zipper
2efr, 2efs, 2d3e - raTPM alpha-1 C-terminal+GNC4 leucine zipper – rabbit
4a7f, 4a7h, 4a7l - raTPM α-1 + myosin + actin – Cryo EM
3j4k - raTPM + actin – Cryo EM
1kql - TPM alpha-1 C-terminal+GNC4 leucine zipper - rat
1mv4 - rTPM alpha-1 C-terminal
2g9j - rTPM alpha-1 TM9A+GNC4
2b9c – rTPM mid region
3azd – rTPM N terminal
1c1g – TPM – pig
2tma – TPM - model


References

  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 1.16 1.17 1.18 1.19 1.20 1.21 1.22 1.23 1.24 Tropomyosins. I. Gunning, Peter, 1950- II. Series.[DNLM: 1. Tropomyosin. W1 AD559 v.644 2008 / WE 500 T856 2008]
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Frye J, Klenchin VA, Rayment I. Structure of the tropomyosin overlap complex from chicken smooth muscle: insight into the diversity of N-terminal recognition . Biochemistry. 2010 Jun 15;49(23):4908-20. PMID:20465283 doi:10.1021/bi100349a
  3. 3.0 3.1 3.2 Whitby FG, Phillips GN Jr. Crystal structure of tropomyosin at 7 Angstroms resolution. Proteins. 2000 Jan 1;38(1):49-59. PMID:10651038
  4. 4.0 4.1 4.2 Clayton JE, Sammons MR, Stark BC, Hodges AR, Lord M. Differential regulation of unconventional fission yeast myosins via the actin track. Curr Biol. 2010 Aug 24;20(16):1423-31. Epub 2010 Aug 12. PMID:20705471 doi:10.1016/j.cub.2010.07.026
  5. 5.0 5.1 Stark BC, Sladewski TE, Pollard LW, Lord M. Tropomyosin and myosin-II cellular levels promote actomyosin ring assembly in fission yeast. Mol Biol Cell. 2010 Mar 15;21(6):989-1000. Epub 2010 Jan 28. PMID:20110347 doi:10.1091/mbc.E09-10-0852
  6. 6.0 6.1 Drees B, Brown C, Barrell BG, Bretscher A. Tropomyosin is essential in yeast, yet the TPM1 and TPM2 products perform distinct functions. J Cell Biol. 1995 Feb;128(3):383-92. PMID:7844152
  7. 7.0 7.1 7.2 7.3 7.4 Lehman W, Galinska-Rakoczy A, Hatch V, Tobacman LS, Craig R. Structural basis for the activation of muscle contraction by troponin and tropomyosin. J Mol Biol. 2009 May 15;388(4):673-81. Epub 2009 Mar 31. PMID:19341744 doi:10.1016/j.jmb.2009.03.060
  8. 8.0 8.1 Tyska MJ, Warshaw DM. The myosin power stroke. Cell Motil Cytoskeleton. 2002 Jan;51(1):1-15. PMID:11810692 doi:10.1002/cm.10014

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