Thiaminase

From Proteopedia

Thiaminase II complex with pyrimidine derivative 1yak Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Thiaminase (Thi) or thiamine pyridinylase cleaves vitamin B1. Thiaminase I catalyzes the elimination of the thiazole ring moiety from the thiamin through substitution of the methylene group with a nitrogenous base or sulfhydryl compound[1]. Thiaminase II catalyzes the hydrolysis of thiamin [2]. Structural highlights The . and the [3].

3D Structures of thiaminase

Updated on 25-November-2020

References

1. ↑ Kreinbring CA, Remillard SP, Hubbard P, Brodkin HR, Leeper FJ, Hawksley D, Lai EY, Fulton C, Petsko GA, Ringe D. Structure of a eukaryotic thiaminase I. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):137-42. doi: 10.1073/pnas.1315882110., Epub 2013 Dec 18. PMID:24351929 doi:http://dx.doi.org/10.1073/pnas.1315882110
2. ↑ Onozuka M, Konno H, Kawasaki Y, Akaji K, Nosaka K. Involvement of thiaminase II encoded by the THI20 gene in thiamin salvage of Saccharomyces cerevisiae. FEMS Yeast Res. 2008 Mar;8(2):266-75. Epub 2007 Nov 19. PMID:18028398 doi:http://dx.doi.org/10.1111/j.1567-1364.2007.00333.x
3. ↑ Toms AV, Haas AL, Park JH, Begley TP, Ealick SE. Structural characterization of the regulatory proteins TenA and TenI from Bacillus subtilis and identification of TenA as a thiaminase II. Biochemistry. 2005 Feb 22;44(7):2319-29. PMID:15709744 doi:http://dx.doi.org/10.1021/bi0478648