Function
Proto-oncogene serine/threonine-protein kinase (Pim1) is the provirus integration site for Moloney murine leukemia virus 1[1]. Pim1 is involved in cell cycle progression, apoptosis, transcriptional activation and signaling pathways. Pim1 phosphorylates and inhibits proapoptotic proteins. For details see Student Project 6 for UMass Chemistry 423 Spring 2015. See also Oncogenes & Tumor Suppressor Genes.
Relevance
Pim1 is a progression marker in diffuse large B-cell lymphoma[2].
Disease
Pim-1 plays a pivotal role in several tumor relevant signaling pathways and is relevant to colon carcinoma[3].
Structural highlights
Pim1 is phosphorylated on serine 261 (PSer). The [4]. Water molecules are shown as red spheres.
pim-1 3D structures
Serine/threonine protein kinase 3D structures