Potassium Channel

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Structure of the Potassium Channel complex with K+ ions, (2r9r)

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This article was developed based on lectures given in Chemistry 543 by Prof. Clarence E. Schutt at Princeton University.


Potassium channels (KCh) are subdivided into voltage-gated KCh and calcium-dependent KCh. The latter are subdivided into high- (BK, LKCa), intermediate- and small-conductance KCh (human SK1, rat SK2, SKCa). The T1 domain is a highly conserved N-terminal domain which is responsible for driving the tetramerization of the KCh α subunit. The inward rectifier KCh (IRK) passes current more easily in the inward direction. MthK is a calcium-dependent KCh from Methanobacterium thermoautrophicum.

3D structures of Potassium Channels

Updated on 20-August-2014

Potassium Channel

1wlj, 2wlh, 2wli, 2wlj, 2wlm, 2wln, 2wlo - MmKCh - Magnetospirillum magnetoacticum
2k44 – KCh voltage-sensor paddle domain – NMR
3e86, 3e83 – BcKCh transmembrane domain – Bacillus cereus
3e8g, 3e89, 3e8b, 3e8f, 3e8h – BcKCh transmembrane domain +ions
2q67, 2q68, 2q69, 2q6a, 3ouf – BcKCh (mutant)
2ahy, 2ahz – BcKCh+ions
1bl8, 1f6g - SlKCh (mutant) - Streptomyces lividans
2qto - SlKCh
1j95 - SlKCh+K+tetrabutylammonium
1jvm - SlKCh (mutant)+Rb+tetrabutylammonium
1jq1, 1jq2 - SlKCh inner transmembrane segment - NMR
3ifx - SlKCh pore domain
3pjs – SlKCh + antibody
2pnv – rKCh leucine zipper domain SKCa – rat
3lut - rKCh Kv1.2 (mutant)
1dsx - rKCh N-terminal (mutant)
1qdv, 1qdw - rKCh Kv1.2 N-terminal
1kn7 - rKCh Kv1.4 N-terminal (mutant) - NMR
1nn7 - rKCh Kv4.2 N-terminal T1 domain
3eau - rKCh β-2 +cortisone
3eb3, 3eb4 - rKCh β-2 (mutant) + cortisone
4hoi – mKCh Kv10.1 PAS domain – mouse
1a68, 1eod, 1eoe, 1eof, 3kvt - AcKCh Kv1.1 T1 domain (mutant) - Aplysia californica
1t1d - AcKCh Kv1.1 T1 domain
1b4g, 1b4i - hKCh inactivation domain - human - NMR
1byw - hKCh ERG N-terminal (mutant)
1ujl - hKCh ERG1 extracellular linker - NMR
2l1m, 2l4r, 2l0w - hKCh HERG - NMR
1s1g - hKCh Kv4.3 T1 domain
2ovc - hKCh Kv7.4 T1 domain
3bj4 - hKCh Kv7.1 C-termianl
3hfc, 3hfe - hKCh Kv7.1 (mutant)
4bw5 – hKCh TREK-2
1zsx - hKCh β-2
1ztn – hKCH RAW3 inactivation gate – NMR
1zto - hKCH RCK4 inactivation gate – NMR
3co2, 1vp6 - MlotiK1 cyclic nucleotide binding domain - Mesorhizobium loti
1ho2, 1ho7 - KCh L45 segment - Drosophila melanogaster - NMR
2kyh - AeKCh voltage ensing domain - Aeropyrum pernix - NMR
2wll - KCh KIRBAC1.1 - Burkholderia pseudomalie
1bei - KCh Kv1.3 – Stichodactyla helianthus

Potassium channel complex with protein

2nz0 – hKCh Kv4.3 N-terminal+KV channel interacting protein 1
2i2r - rKCh Kv4.3 N-terminal+KV channel interacting protein 1
1s6c - rKCh Kv4.2 N-terminal+KV channel interacting protein 1
2a79, 1qrq - rKCh Kv1.2 + beta2
4jta, 4jtc, 4jtd - rKCh Kv1.2-2.1 + KCh toxin
2r9r - rKCh
1qx7 – rKCh SKCa+ calmodulin
1g4y – rKCh rSK2 calmodulin binding domain SKCa + calmodulin
1exb - rKCh Kv1.1 T1 domain + KV beta2 protein
2p7t - rKCh + FAV
3lnm - rKCh Kv2.1/KCh Kv1.2 (mutant)
3eff - mKCh + FAB
2w0f - mKCh + FAB + tetraoctylammonium
2hg5, 2h8p, 2hfe - KCh + mFAB
3f7v, 3f7y, 3fb5, 3fb7, 3fb8, 3gb7, 3hpl, 3iga, 3or6, 3or7, 1r3i, 1r3j, 1r3k,1r3l, 1s5h, 2atk, 2bob, 2boc, 2dwd, 2dwe, 2hvj, 2hvk, 2ih1, 2ih3, 2itc, 2itd, 2jk5, 2nlj - mKCh (mutant) + FAB
3f5w, 1zwi, 2hjf - mKCh (mutant) + antibody heavy+light chains
1k4c, 1k4d - SlKCh (mutant) + antibody heavy+light chains
2a0l - AeKCh + FV
1orq - AeKCh (mutant) + FAB
2a9h - SlKCh (mutant) + charybdotoxin

Inward rectifier KCh

1u4f,3agw - mIRK 2 cytoplasmic domain
2xky - mIRK 2 cytoplasmic domain - EM
2gix, 3vsq - mIRK 2 cytoplasmic domain (mutant)
2e4f - mIRK 2 fragment
1n9p, 1u4e - mIRK 1 cytoplasmic domain
3k6n - mIRK 1 cytoplasmic domain (mutant)
3at8, 3at9, 3ata, 3atb, 3atd, 3ate, 3atf, 3auw, 3syo - mIRK 3.2
3syc, 3syp - mIRK 3.2 (mutant)
3sya - mIRK 3.2 + PIP2
3syq - mIRK 3.2 (mutant) + PIP2
4kfm - mIRK 3.2 + guanine nucleotide-biding protein
1xl4, 1xl6, 2wlk, 2x6a, 2x6b, 2x6c - MmIRK KIRBAC3.1
4lp8 - MmIRK KIRBAC3.1 (mutant)
1p7b - BpIRK C-terminal
3spc – cIRK 2.2 + DGPP – chicken
3spg, 3sph – cIRK 2.2 (mutant) + PIP2
3spi – cIRK 2.2 + PIP2
3spj – cIRK 2.2 (mutant)
3ukm – hIRK TWIK-1
3um7 – hIRK TRAAK
3zrs – MmIRK 10

MthK

2ogu, 2fy8, 2aej, 2aem, 1lnq - MthK RCK domain - Methanobacterium thermoautrophicum
3ldc, 3ldd, 3lde, 3ous – MthK residues 28-99 (mutant)
2aef, 3kxd, 4ei2, 4l73, 4l74, 4l75, 4l76 - MthK RCK domain + Ca
3rbx, 3rbz - MthK RCK domain (mutant) + Ca
3r65, 4hyo, 4hz3 – MthK pore domain (mutant)

Large conductance calcium-activated KCh

3mt5 - hBK cytoplasmic domain
1jo6 - BK beta 2 N-terminal KCNMB2 encoded LKCa - NMR
3u6n – BK – Danio rerio

Potassium/Sodium channel

3k03, 3k04, 3k06, 3k08, 3k0d, 3k0g – BcNaK
3t1c, 3t2m, 3t4d, 3t4z, 3tcu, 3tet – BcNaK (mutant)

Potassium/Sodium hyperpolarization-activated cyclic nucleotide-gated channel or cyclic nucleotide-gated channel or HCN channel

Ion channels

Calcium-activated KCh

3naf – hKCh α1 subunit

Small conductance calcium-activated KCh

1kkd – rKCh calmodulin-binding domain - NMR - rat
3sjq, 4g27, 4g28, 4j9y, 4j9z - rKCh calmodulin-binding domain + calmodulin
2pnv – rKCh leucine zipper domain SKCa


Additional Resources

For Additional Information, See: Membrane Channels & Pumps

References


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