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Pharmaceutical Drugs

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AstraZeneca’s Nexium
AstraZeneca’s Nexium

The Pharmaceutical industry is one of the world’s largest industries, grossing well over $300 billion in the United States alone. Understanding how the drugs the pharma industry develops work and different characteristics of these compounds is important to nearly everyone as 50% of the US population takes at least one prescription medication regularly and nearly everyone takes a pharmaceutical pill at some point in their life.[1] The following is a growing list of pharmaceutical compounds organized by disorder.

See Pharmaceutical Drug Targets for a list of drug targets organized by disease.

The majority of all modern medicinal drugs target members of the superfamily of proteins called the G protein-coupled receptors or GPCRs[2][3].

Treatments

The following is a list of pharmaceutical treatments for various diseases, organized by disorder. Each entry highlights general information about the therapeutic, pharmacokinetic data comparisons within its drug class, and a structural analysis explaining how the drug compound functions in vivo.

Alzheimer's Disease

Bacterial Infection

Cancer
Acetylcholinesterase Inhibitors
Macrolide Antibiotics
  • Biaxin: - Generic: Clarithromycin
  • Dynabac - Generic: Dirithromycin
  • Ketek - Generic: Telithromycin
  • Llosone - Generic: Erythromycin
  • Rulide - Generic: Roxithromycin
  • Zithromax - Generic: Azithromycin
Anti-CD20 Monoclonal Antibody
B-Raf Kinase Inhibitor
  • Zelboraf - Generic: Vemurafenib (Formerly: PLX-4032)
Chemotherapy
  • Platinol - Generic: Cisplatin
Dihydrofolate Reductase Inhibitor
  • Alimta - Generic: Pemetrexed
  • Folotyn - Generic: Pralatrexate
  • Methotrexate
  • Raltitrexed
Epidermal Growth Factor Receptor Inhibitor
Estrogen Receptor Modulator
  • Evista - Generic: Raloxifene
  • Fareston - Generic: Toremifene
  • Nolvadex - Generic: Tamoxifen
Multiple Receptor Tyrosine Kinase (VEGFR, PDGFR, EGFR, KIT, Abl) Inhibitor
Vascular Endothelial Growth Factor Inhibitor

Depression

Diabetes

Erectile Dysfunction

Serotonin Transporter Inhibitors

Tricyclic Antidepressants
  • Anafranil - Generic: Chlomipramine
Selective Serotonin Reuptake Inhibitors
  • Prozac - Generic: Fluoxetine
  • Xoloft - Generic: Sertraline


Dipeptidyl Peptidase-4 Inhibitor
Peroxisome Proliferator-Activated Receptor Agonist
  • Actos - Generic: Pioglitazone
  • Avandia - Generic: Rosiglitazone
Phosphodiesterase Type 5 Inhibitor
  • Cialis - Generic: Tadalafil
  • Levitra - Generic: Vardenafil
  • Viagra - Generic: Sildenafil

Hypercholeseterolemia

Hypertension

HIV
HMG-CoA Reductase Inhibitors (Statins)
Angiotensin-Converting Enzyme Inhibitors
β-Adrenergic Receptor Antagonists
  • Betoptic - Generic: Betaxolol
  • Blocadren - Generic: Timolol
  • Bystolic - Generic: Nebivolol
  • Coreg - Generic: Carvedilol
  • Gubernal - Generic: Alprenolol
  • Inderal - Generic: Propranolol
  • Lopressor - Generic: Metroprolol
  • Trandate - Generic: Labetalol
  • Visken - Generic: Pindolol
  • Zebeta - Generic: Bisoprolol
Chemokine Receptor Type 5 (CCR5) Inhibitors
  • Selzentry - Generic: Maraviroc
HIV-Protease Inhibitors
Non-Nucleoside Reverse Transcriptase Inhibitors
  • Intelence - Generic: Etravirine
  • Rescriptor - Generic: Delvirdine
  • Sustiva - Generic: Efavirenz
  • Viramune - Generic: Nevirapine
Nucleoside Analog Reverse Transcriptase Inhibitors
  • Baraclude - Generic: Entecavir
  • Emtriva - Generic: Emtricitabine
  • Epivir - Generic: Lamivudine
  • Hivid - Generic: Zalcitabine
  • Retrovir - Generic: Zidovudine
  • Videx - Generic: Didanosine
  • Viread - Generic: Tenofovir
  • Zerit - Generic: Stavudine
  • Ziagen - Generic: Abacavir
Retroviral Integrase Inhibitors


Inflammation & Arthritis

Influenza

--
Cyclooxygenase Inhibitors
  • Advil - Generic: Ibuprofen
  • Aleve - Generic: Naproxen
  • Ansaid - Generic: Flurbiprofen
  • Aspirin - Generic: Acetylsalicylic Acid
  • Bextra - Generic: Valdecoxib
  • Celebrex - Generic: Celecoxib
  • Clinoril - Generic: Sulindac
  • Daypro - Generic: Oxaprozin
  • Feldene - Generic: Piroxicam
  • Relafen - Generic: Nabumetone
  • Paracetamol - Generic: Acetaminophen
  • Ponstel - Generic: Mefanamic Acid
  • Toradol - Generic: Ketorolac
  • Vioxx - Generic: Rofecoxib
  • Voltaren - Generic: Diclofenac
M2 Proton Channel Inhibitors
Neuraminidase Inhibitors


References

  1. ↑ http://www.npr.org/blogs/health/2010/09/03/129626052/a-portrait-of-health-prescription-drugs-in-america
  2. ↑ Overington JP, Al-Lazikani B, Hopkins AL. How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. PMID:17139284 doi:10.1038/nrd2199
  3. ↑ Peeters MC, van Westen GJ, Li Q, IJzerman AP. Importance of the extracellular loops in G protein-coupled receptors for ligand recognition and receptor activation. Trends Pharmacol Sci. 2011 Jan;32(1):35-42. PMID:21075459 doi:10.1016/j.tips.2010.10.001


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