Polyhydroxybutyrate synthase

From Proteopedia

Polyhydroxybutyrate synthase catalytic domain complex with glycerol and sulfate (PBD code 5hz2) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Polyhydroxybutyrate synthase (PHBS) or PHB synthase catalyze the polymerization of β-hydroxybutyryl coenzyme A to generate polyhydroxybutyrate[1]. For details see PHB synthase in Rhodobacter sphaeroides. Relevance PHB is of interest as bio-derived and biodegradable plastics.

3D structures of PHB synthase

5t6o, 5hz2 - PHBS catalytic domain - Cupriavidus necator

References

1. ↑ Jia Y, Yuan W, Wodzinska J, Park C, Sinskey AJ, Stubbe J. Mechanistic studies on class I polyhydroxybutyrate (PHB) synthase from Ralstonia eutropha: class I and III synthases share a similar catalytic mechanism. Biochemistry. 2001 Jan 30;40(4):1011-9. PMID:11170423