Nitroreductase

Function

Nitroreductase or oxygen-insensitive NAD(P)H nitroreductase (NR) is involved in the reduction of nitrogen-containing compounds including those containing NO₂ group. The NO₂ group is reduced to hydroxylamine^[1]. NR uses FMN as cofactor. Among NRs are the oxygen-insensitive NAD(P)H NR and NADH dehydrogenase.

Relevance

NR is of special interest due to its potential use as activator of prodrugs in cancer therapy^[2].

Structural highlights

NR while the . Water molecules are shown as red spheres.

3D structures of nitroreductase

Nitroreductase 3D structures