Function
MECDP synthase or 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS) participates in mevalonate-independent steroid biosynthesis. It converts 2-phospho-4-(cytidine 5’-diphospho)-2-C-methyl-D-erythritol (2P-CDME) to 2-C-methyl-D-erythritol 2, 4-cyclodiphosphate (MECP) and CMP. MECPS contains metal binding sites which are required for catalysis[1].
Relevance
MECPS is a potential antimalarial drug target[2].
Structural highlights
and contains the [3]. Water molecules are shown as red spheres.
3D structures of MECDP synthase
MECDP synthase 3D structures