DNA repair protein Rad4

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Structure of yeast Rad4 (green) complex with Rad23 (magenta) and DNA (PDB entry 2qsg)

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3D Structures of DNA repair protein Rad4

Updated on 06-February-2023

2qsf – yRad4 + Rad23 - yeast
2qsg, 2qsh, 4yir, 6cfi, 6ubf, 6ug1, 6uin – yRad4 + Rad23 + DNA
7k04 – yRad4 + Rad23 + Rad33 + TFIIH + DNA – Cryo EM
7m2u – yRad4 + Rad23 + Rad25 + Rad33 + TFIIH + DNA – Cryo EM
2m14 – yRad4 internal UBA domain + RNA polymerase II TFB1 - NMR
4bu0, 4bu1, 6hm3, 6hm4 – fyRad4 BRCT1 domain + phosphopeptide – fission yeast
4bmc – fyRad4 BRCT1 + BRCT2 domains
4bmd – fyRad4 BRCT3 + BRCT4 domains

References

  1. den Dulk B, Brandsma JA, Brouwer J. The Rad4 homologue YDR314C is essential for strand-specific repair of RNA polymerase I-transcribed rDNA in Saccharomyces cerevisiae. Mol Microbiol. 2005 Jun;56(6):1518-26. doi: 10.1111/j.1365-2958.2005.04607.x. PMID:15916602 doi:http://dx.doi.org/10.1111/j.1365-2958.2005.04607.x
  2. Velmurugu Y, Chen X, Slogoff Sevilla P, Min JH, Ansari A. Twist-open mechanism of DNA damage recognition by the Rad4/XPC nucleotide excision repair complex. Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):E2296-305. doi:, 10.1073/pnas.1514666113. Epub 2016 Mar 31. PMID:27035942 doi:http://dx.doi.org/10.1073/pnas.1514666113
  3. Min JH, Pavletich NP. Recognition of DNA damage by the Rad4 nucleotide excision repair protein. Nature. 2007 Oct 4;449(7162):570-5. Epub 2007 Sep 19. PMID:17882165 doi:10.1038/nature06155
  4. Min JH, Pavletich NP. Recognition of DNA damage by the Rad4 nucleotide excision repair protein. Nature. 2007 Oct 4;449(7162):570-5. Epub 2007 Sep 19. PMID:17882165 doi:10.1038/nature06155

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