Catabolite gene activator protein (CAP) is a DNA-binding protein involved in the transcription of several genes including those involved in the metabolism of sugar. CAP can activate or repress transcription initiation upon binding of cAMP. The cAMP-CAP complex binds to promoters on the DNA. The structure contains a ligand-binding domain (LBD) at the N-terminal and DNA-binding domain (DBD) at the C-terminal. . When the amount of glucose transported into the cell is low, cAMP level rises and the cAMP-CAP complex causes increase of transcription of glucose metabolism genes. [1]
See also CAMP-dependent pathway and CAMP is second messenger.
in E. coli Catabolite gene activator protein (1o3r). [2] Water molecules are shown as red spheres.
3D Structures of catabolite gene activator protein
Catabolite gene activator protein 3D structures
