Carbamazepine, sold under the brand name Tegretol among others, is an anticonvulsant medication used in the treatment of epilepsy and neuropathic pain.[1][2] It is used as an adjunctive treatment in schizophrenia along with other medications and as a second-line agent in bipolar disorder.[3][2] Carbamazepine appears to work as well as phenytoin and valproate for focal and generalized seizures.[4] It is not effective for absence or myoclonic seizures.[2] See also Carbamazepine.
Carbamazepine is a sodium channel blocker.[5] It binds preferentially to voltage-gated sodium channels (Nav) in their inactive conformation, which prevents repetitive and sustained firing of an action potential.
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