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6tmn

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6tmn, resolution 1.60Å ()
Ligands: , ,
Activity: Thermolysin, with EC number 3.4.24.27
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Contents

Structures of two thermolysin-inhibitor complexes that differ by a single hydrogen bond

Publication Abstract from PubMed

The mode of binding to thermolysin of the ester analog Cbz-GlyP-(O)-Leu-Leu has been determined by x-ray crystallography and shown to be virtually identical (maximum difference 0.2 angstrom) with the corresponding peptide analog Cbz-GlyP-(NH)-Leu-Leu. The two inhibitors provide a matched pair of enzyme-inhibitor complexes that differ by 4.1 kilocalories per mole in intrinsic binding energy but are essentially identical except for the presence or absence of a specific hydrogen bond.

Structures of two thermolysin-inhibitor complexes that differ by a single hydrogen bond., Tronrud DE, Holden HM, Matthews BW, Science. 1987 Jan 30;235(4788):571-4. PMID:3810156

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

6tmn is a 1 chain structure with sequence from Bacillus thermoproteolyticus. Full crystallographic information is available from OCA.

See Also

Reference

  • Tronrud DE, Holden HM, Matthews BW. Structures of two thermolysin-inhibitor complexes that differ by a single hydrogen bond. Science. 1987 Jan 30;235(4788):571-4. PMID:3810156

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