5lxo
From Proteopedia
Jump to: navigation, search
proteopedia linkproteopedia linkCoiled-coil protein
Structural highlights
DiseaseTACC3_HUMAN Gliosarcoma;Giant cell glioblastoma. FunctionTACC3_HUMAN Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476).[UniProtKB:Q9JJ11][1] [2] [3] References
| ||||||||||||||||||||
Retrieved from "http://proteopedia.org/wiki/index.php/5lxo"
