Structural highlights
Disease
KAP0_HUMAN Acute promyelocytic leukemia;Acrodysostosis with multiple hormone resistance;Familial atrial myxoma;Primary pigmented nodular adrenocortical disease;Carney complex;Acrodysostosis. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
Function
KAP0_HUMAN Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.[1] [2] [3]
See Also
References
- ↑ Glesne D, Huberman E. Smad6 is a protein kinase X phosphorylation substrate and is required for HL-60 cell differentiation. Oncogene. 2006 Jul 6;25(29):4086-98. Epub 2006 Feb 20. PMID:16491121 doi:http://dx.doi.org/1209436
- ↑ Santos NC, Kim KH. Activity of retinoic acid receptor-alpha is directly regulated at its protein kinase A sites in response to follicle-stimulating hormone signaling. Endocrinology. 2010 May;151(5):2361-72. doi: 10.1210/en.2009-1338. Epub 2010 Mar , 9. PMID:20215566 doi:10.1210/en.2009-1338
- ↑ Rhayem Y, Le Stunff C, Abdel Khalek W, Auzan C, Bertherat J, Linglart A, Couvineau A, Silve C, Clauser E. Functional Characterization of PRKAR1A Mutations Reveals a Unique Molecular Mechanism Causing Acrodysostosis but Multiple Mechanisms Causing Carney Complex. J Biol Chem. 2015 Nov 13;290(46):27816-28. doi: 10.1074/jbc.M115.656553. Epub, 2015 Sep 24. PMID:26405036 doi:http://dx.doi.org/10.1074/jbc.M115.656553