Structural highlights
4kvl is a 1 chain structure with sequence from Oryza sativa. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | X-ray diffraction, Resolution 1.96Å |
| Ligands: | , , , , , , , , |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
PIOX_ORYSJ Alpha-dioxygenase that catalyzes the primary oxygenation step of a variety of 14-20 carbon fatty acids, containing up to three unsaturated bonds, into their corresponding 2R-hydroperoxides (PubMed:11909851, PubMed:18596034). Involved in the production of oxylipins that function in cell signaling, wound healing, and protection from infection (PubMed:11909851, PubMed:18596034).[1] [2]
References
- ↑ Koeduka T, Matsui K, Akakabe Y, Kajiwara T. Catalytic properties of rice alpha-oxygenase. A comparison with mammalian prostaglandin H synthases. J Biol Chem. 2002 Jun 21;277(25):22648-55. doi: 10.1074/jbc.M110420200. Epub 2002 , Mar 21. PMID:11909851 doi:http://dx.doi.org/10.1074/jbc.M110420200
- ↑ Koszelak-Rosenblum M, Krol AC, Simmons DM, Goulah CC, Wroblewski L, Malkowski MG. His-311 and Arg-559 are key residues involved in fatty acid oxygenation in pathogen-inducible oxygenase. J Biol Chem. 2008 Sep 5;283(36):24962-71. doi: 10.1074/jbc.M804358200. Epub 2008 , Jul 2. PMID:18596034 doi:http://dx.doi.org/10.1074/jbc.M804358200
