Structural highlights
Function
HDHD1_HUMAN Dephosphorylates pseudouridine 5'-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine.[1]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
- ↑ Preumont A, Rzem R, Vertommen D, Van Schaftingen E. HDHD1, which is often deleted in X-linked ichthyosis, encodes a pseudouridine-5'-phosphatase. Biochem J. 2010 Oct 15;431(2):237-44. doi: 10.1042/BJ20100174. PMID:20722631 doi:http://dx.doi.org/10.1042/BJ20100174