Structural highlights
Function
MECA2_BACSU Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Also involved in Spx degradation by ClpC (By similarity). Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation.[1]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
- ↑ Persuh M, Mandic-Mulec I, Dubnau D. A MecA paralog, YpbH, binds ClpC, affecting both competence and sporulation. J Bacteriol. 2002 Apr;184(8):2310-3. PMID:11914365
