First time at Proteopedia? Click on the green links: they change the 3D image. Click and drag the molecules. Proteopedia is a 3D, interactive encyclopedia of proteins, RNA, DNA and other molecules. With a free user account, you can edit pages in Proteopedia. Visit the Main Page to learn more.

3hmj

From Proteopedia

Jump to: navigation, search
Warning: this is a large structure, and loading might take a long time or not happen at all.
3hmj, resolution 4.00Å ()
Ligands: ,
Gene: FAS2 (Saccharomyces cerevisiae), FAS1 (Saccharomyces cerevisiae)
Activity: Fatty-acyl-CoA synthase, with EC number 2.3.1.86
Related: 2vkz
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml


Contents

Saccharomyces cerevisiae FAS type I

Publication Abstract from PubMed

The fungal type I fatty acid synthase (FAS) is a 2.6 MDa multienzyme complex, catalyzing all necessary steps for the synthesis of long acyl chains. To be catalytically competent, the FAS must be activated by a posttranslational modification of the central acyl carrier domain (ACP) by an intrinsic phosphopantetheine transferase (PPT). However, recent X-ray structures of the fungal FAS revealed a barrel-shaped architecture, with PPT located at the outside of the barrel wall, spatially separated from the ACP caged in the inner volume. This separation indicated that the activation has to proceed before the assembly to the mature complex, in a conformation where the ACP and PPT domains can meet. To gain insight into the auto-activation reaction and also into the fungal FAS assembly pathway, we structurally and functionally characterized the Saccharomyces cerevisiae FAS type I PPT as part of the multienzyme protein and as an isolated domain.

Multimeric options for the auto-activation of the Saccharomyces cerevisiae FAS type I megasynthase., Johansson P, Mulinacci B, Koestler C, Vollrath R, Oesterhelt D, Grininger M, Structure. 2009 Aug 12;17(8):1063-74. PMID:19679086

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

3hmj is a 6 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

See Also

Reference

  • Johansson P, Mulinacci B, Koestler C, Vollrath R, Oesterhelt D, Grininger M. Multimeric options for the auto-activation of the Saccharomyces cerevisiae FAS type I megasynthase. Structure. 2009 Aug 12;17(8):1063-74. PMID:19679086 doi:10.1016/j.str.2009.06.014

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools