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3e5h
From Proteopedia
| 3e5h, resolution 1.50Å () | |||||||||
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| Sites: | , , and | ||||||||
| Ligands: | , , | ||||||||
| Gene: | rab28 (Homo sapiens) | ||||||||
| Related: | 2hxs | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Crystal Structure of Rab28 GTPase in the Active (GppNHp-bound) Form
Rab GTPases are essential regulators of membrane trafficking. We report crystal structures of Rab28 in the active (GppNHp-bound) and inactive (GDP-3'P-bound) forms at 1.5 and 1.1A resolution. Rab28 is a distant member of the Rab family. While the overall fold of Rab28 resembles that of other Rab GTPases, it undergoes a larger nucleotide-dependent conformational change than other members of this family. Added flexibility resulting from a double-glycine motif at the beginning of switch 2 might partially account for this observation. The double-glycine motif, which is conserved in the Arf family, only occurs in Rab28 and Rab7B of the Rab family, and may have a profound effect on their catalytic activities.
Large nucleotide-dependent conformational change in Rab28., Lee SH, Baek K, Dominguez R, FEBS Lett. 2008 Dec 10;582(29):4107-11. Epub 2008 Nov 19. PMID:19026641
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
3E5H is a 1 chain structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 2hy4. Full crystallographic information is available from OCA.
Reference
- Lee SH, Baek K, Dominguez R. Large nucleotide-dependent conformational change in Rab28. FEBS Lett. 2008 Dec 10;582(29):4107-11. Epub 2008 Nov 19. PMID:19026641 doi:10.1016/j.febslet.2008.11.008
Page seeded by OCA on Tue Feb 17 00:51:37 2009
