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3cw3
From Proteopedia
| 3cw3, resolution 1.88Å () | |||||||||||
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| Gene: | AIM1 (Homo sapiens) | ||||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||
Contents |
Crystal structure of AIM1g1
Betagamma-crystallins belong to a superfamily of proteins in prokaryotes and eukaryotes that are based on duplications of a characteristic, highly conserved Greek key motif. Most members of the superfamily in vertebrates are structural proteins of the eye lens that contain four motifs arranged as two structural domains. Absent in melanoma 1 (AIM1), an unusual member of the superfamily whose expression is associated with suppression of malignancy in melanoma, contains 12 betagamma-crystallin motifs in six domains. Some of these motifs diverge considerably from the canonical motif sequence. AIM1g1, the first betagamma-crystallin domain of AIM1, is the most variant of betagamma-crystallin domains currently known. In order to understand the limits of sequence variation on the structure, we report the crystal structure of AIM1g1 at 1.9 A resolution. Despite having changes in key residues, the domain retains the overall betagamma-crystallin fold. The domain also contains an unusual extended surface loop that significantly alters the shape of the domain and its charge profile. This structure illustrates the resilience of the betagamma fold to considerable sequence changes and its remarkable ability to adapt for novel functions.
Exploring the limits of sequence and structure in a variant betagamma-crystallin domain of the protein absent in melanoma-1 (AIM1)., Aravind P, Wistow G, Sharma Y, Sankaranarayanan R, J Mol Biol. 2008 Sep 5;381(3):509-18. Epub 2008 Jun 14. PMID:18582473
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
Disease
Known disease associated with this structure: Oculocutaneous albinism, type IV OMIM:[606202], Skin/hair/eye pigmentation 5, black/nonblack hair OMIM:[606202], Skin/hair/eye pigmentation 5, dark/fair skin OMIM:[606202], Skin/hair/eye pigmentation 5, dark/light eyes OMIM:[606202]
About this Structure
3CW3 is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Aravind P, Wistow G, Sharma Y, Sankaranarayanan R. Exploring the limits of sequence and structure in a variant betagamma-crystallin domain of the protein absent in melanoma-1 (AIM1). J Mol Biol. 2008 Sep 5;381(3):509-18. Epub 2008 Jun 14. PMID:18582473 doi:10.1016/j.jmb.2008.06.019
Page seeded by OCA on Mon Feb 16 14:20:26 2009
