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2nvz, resolution 4.30Å ()
Ligands: , ,
Activity: DNA-directed RNA polymerase, with EC number
Related: 1r9s, 1r9t, 1sfo, 2e2h, 2e2i, 2e2j, 2nvq, 2nvs, 2nvt, 2nvx, 2nvy
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml


RNA Polymerase II elongation complex with UTP, updated 11/2006

Publication Abstract from PubMed

New structures of RNA polymerase II (pol II) transcribing complexes reveal a likely key to transcription. The trigger loop swings beneath a correct nucleoside triphosphate (NTP) in the nucleotide addition site, closing off the active center and forming an extensive network of interactions with the NTP base, sugar, phosphates, and additional pol II residues. A histidine side chain in the trigger loop, precisely positioned by these interactions, may literally "trigger" phosphodiester bond formation. Recognition and catalysis are thus coupled, ensuring the fidelity of transcription.

Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis., Wang D, Bushnell DA, Westover KD, Kaplan CD, Kornberg RD, Cell. 2006 Dec 1;127(5):941-54. PMID:17129781

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

2nvz is a 13 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

See Also


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