Structural highlights
Function
[TR30A_MOUSE] Trans-acting factor that regulates gene expression of interleukin 2 receptor alpha chain. May affect IL2R-alpha expression through cis-acting negative regulatory elements or through competition with proteins that bind to enhancer or activator sequences. Negatively regulates Toll-like receptor (TLR)-mediated activation of NFKB by promoting degradation of TAB2 and TAB3 and preventing TRAF6 autoubiquitination. Negatively regulates production of reactive oxygen species (ROS) which inhibits activation of the NLRP3 inflammasome complex. This, in turn, regulates activation of CASP1 and subsequent cleavage of IL1B and IL18. No activity detected against a range of retroviruses including a number of lentiviruses, gammaretroviruses and betaretroviruses.[1] [2] [3]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
- ↑ Shi M, Deng W, Bi E, Mao K, Ji Y, Lin G, Wu X, Tao Z, Li Z, Cai X, Sun S, Xiang C, Sun B. TRIM30 alpha negatively regulates TLR-mediated NF-kappa B activation by targeting TAB2 and TAB3 for degradation. Nat Immunol. 2008 Apr;9(4):369-77. doi: 10.1038/ni1577. Epub 2008 Mar 16. PMID:18345001 doi:http://dx.doi.org/10.1038/ni1577
- ↑ Tareen SU, Sawyer SL, Malik HS, Emerman M. An expanded clade of rodent Trim5 genes. Virology. 2009 Mar 15;385(2):473-83. doi: 10.1016/j.virol.2008.12.018. Epub 2009 , Jan 15. PMID:19147168 doi:http://dx.doi.org/10.1016/j.virol.2008.12.018
- ↑ Hu Y, Mao K, Zeng Y, Chen S, Tao Z, Yang C, Sun S, Wu X, Meng G, Sun B. Tripartite-motif protein 30 negatively regulates NLRP3 inflammasome activation by modulating reactive oxygen species production. J Immunol. 2010 Dec 15;185(12):7699-705. doi: 10.4049/jimmunol.1001099. Epub 2010, Nov 3. PMID:21048113 doi:http://dx.doi.org/10.4049/jimmunol.1001099
