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1zyy

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Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.


1zyy ()
Resources: FirstGlance, PDBsum
Coordinates: save as pdb, mmCIF, xml



STRUCTURAL MODEL FOR THE ADDUCT BETWEEN CYTOCHROME C AND CYTOCHROME C OXIDASE

Publication Abstract from PubMed

An ensemble of structural models of the adduct between cytochrome c and cytochrome c oxidase from Paracoccus denitrificans has been calculated based on the experimental data from site-directed mutagenesis and NMR experiments that have accumulated over the last years of research on this system. The residues from each protein that are at the protein-protein interface have been identified by the above experimental work, and this information has been converted in a series of restraints explicitly used in calculations. It is found that a single static structural model cannot satisfy all experimental data simultaneously. Therefore, it is proposed that the adduct exists as a dynamic ensemble of different orientations in equilibrium, and may be represented by a combination or average of the various limiting conformations calculated here. The equilibrium involves both conformations that are competent for electron transfer and conformations that are not. Long-range recognition of the partners is driven by non-specific electrostatic interactions, while at shorter distances hydrophobic contacts tune the reciprocal orientation. Electron transfer from cytochrome bc (1) to cytochrome c oxidase is mediated through cytochrome c experiencing multiple encounters with both of its partners, only part of which are productive. The number of encounters, and thus the electron transfer rate, may be increased by the formation of a cytochrome bc (1)-cytochrome c oxidase supercomplex and/or (in human) by increasing the concentration of the two enzymes in the membrane space.

A structural model for the adduct between cytochrome c and cytochrome c oxidase., Bertini I, Cavallaro G, Rosato A, J Biol Inorg Chem. 2005 Oct;10(6):613-24. Epub 2005 Nov 2. PMID:16151864

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

Reference

  • Bertini I, Cavallaro G, Rosato A. A structural model for the adduct between cytochrome c and cytochrome c oxidase. J Biol Inorg Chem. 2005 Oct;10(6):613-24. Epub 2005 Nov 2. PMID:16151864 doi:10.1007/s00775-005-0011-7

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