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1tr2
From Proteopedia
| 1tr2, resolution 2.90Å () | |||||||||
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| Non-Standard Residues: | |||||||||
| Gene: | VCL (Homo sapiens) | ||||||||
| Domains: | Vinculin | ||||||||
| Related: | 1rke, 1rkc, 1ydi, 1syq | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Contents |
Crystal structure of human full-length vinculin (residues 1-1066)
Alterations in the actin cytoskeleton following the formation of cell-matrix and cell-cell junctions are orchestrated by vinculin. Vinculin associates with a large number of cytoskeletal and signaling proteins, and this flexibility is thought to contribute to rapid dissociation and reassociations of adhesion complexes. Intramolecular interactions between vinculin's head (Vh) and tail (Vt) domains limit access of its binding sites for other adhesion proteins. While the crystal structures of the Vh and Vt domains are known, these domains represent less than half of the entire protein and are separated by a large central region of unknown structure and function. Here we report the crystal structure of human full-length vinculin to 2.85 A resolution. In its resting state, vinculin is a loosely packed collection of alpha-helical bundles held together by Vh-Vt interactions. The three new well ordered alpha-helical bundle domains are similar in their structure to either Vh (Vh2 and Vh3) or to Vt (Vt2) and their loose packing provides the necessary flexibility that allows vinculin to interact with its various protein partners at sites of cell adhesion.
Crystal structure of human vinculin., Borgon RA, Vonrhein C, Bricogne G, Bois PR, Izard T, Structure. 2004 Jul;12(7):1189-97. Epub 2004 Jun 3. PMID:15242595
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
Disease
Known disease associated with this structure: Cardiomyopathy, dilated, 1W OMIM:[193065]
About this Structure
1TR2 is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Borgon RA, Vonrhein C, Bricogne G, Bois PR, Izard T. Crystal structure of human vinculin. Structure. 2004 Jul;12(7):1189-97. Epub 2004 Jun 3. PMID:15242595 doi:10.1016/j.str.2004.05.009
Page seeded by OCA on Mon Feb 16 15:32:04 2009
