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1jm7

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This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

1jm7, 14 NMR models ()

Ligands:

Gene:

BRCA1 (Homo sapiens), BARD1 (Homo sapiens)

Domains:

RING, COG5222

Structural annotation:
Resources:	CATH : 1Jm7A00, 1Jm7B00 InterPro : Ipr011364, Ipr013083, Ipr001357, Ipr001841, Ipr002378, Ipr002110 Pfam : PF00097 SCOP : d1jm7a_, d1jm7b_ UniProt : P38398, Q99728

Functional annotation:
Resources:	GeneCard : BRCA1, BARD1
Cellular component:	gamma-tubulin ring complex BRCA1-BARD1 complex ubiquitin ligase complex intracellular protein complex nucleus cytoplasm
Biological process:	cell cycle regulation of DNA repair chromosome segregation fatty acid biosynthetic process protein ubiquitination regulation of transcription from RNA polymerase II promoter androgen receptor signaling pathway postreplication repair lipid biosynthetic process negative regulation of transcription DNA repair DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator double-strand break repair via homologous recombination regulation of transcription from RNA polymerase III promoter regulation of apoptosis positive regulation of protein ubiquitination DNA damage response, signal transduction resulting in induction of apoptosis response to DNA damage stimulus positive regulation of DNA repair response to estrogen stimulus regulation of cell proliferation negative regulation of fatty acid biosynthetic process apoptosis positive regulation of transcription, DNA-dependent negative regulation of centriole replication negative regulation of cell cycle negative regulation of mRNA 3'-end processing tissue homeostasis negative regulation of protein export from nucleus positive regulation of apoptosis negative regulation of apoptosis cell cycle arrest positive regulation of protein catabolic process regulation of phosphorylation
Molecular function:	zinc ion binding transcription coactivator activity enzyme binding metal ion binding tubulin binding transcription activator activity ubiquitin-protein ligase activity androgen receptor binding protein binding DNA binding protein homodimerization activity kinase binding protein heterodimerization activity RNA binding

Evolutionary conservation:

Toggle Conservation Colors:

Rows = identical sequences:

Further Information:

Caveats,

Explanation,
Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, PDBsum, RCSB

Coordinates:

save as pdb, mmCIF, xml

1 Solution structure of the BRCA1/BARD1 RING-domain heterodimer
2 Disease
3 About this Structure
4 Reference

Solution structure of the BRCA1/BARD1 RING-domain heterodimer

Publication Abstract from PubMed

The RING domain of the breast and ovarian cancer tumor suppressor BRCA1 interacts with multiple cognate proteins, including the RING protein BARD1. Proper function of the BRCA1 RING domain is critical, as evidenced by the many cancer-predisposing mutations found within this domain. We present the solution structure of the heterodimer formed between the RING domains of BRCA1 and BARD1. Comparison with the RING homodimer of the V(D)J recombination-activating protein RAG1 reveals the structural diversity of complexes formed by interactions between different RING domains. The BRCA1-BARD1 structure provides a model for its ubiquitin ligase activity, illustrates how the BRCA1 RING domain can be involved in associations with multiple protein partners and provides a framework for understanding cancer-causing mutations at the molecular level.

Structure of a BRCA1-BARD1 heterodimeric RING-RING complex., Brzovic PS, Rajagopal P, Hoyt DW, King MC, Klevit RE, Nat Struct Biol. 2001 Oct;8(10):833-7. PMID:11573085

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

Disease

Known disease associated with this structure: Breast cancer-1 OMIM:[113705], Breast-ovarian cancer OMIM:[113705], Ovarian cancer OMIM:[113705], Papillary serous carcinoma of the peritoneum OMIM:[113705], Breast cancer, susceptibility to OMIM:[601593]

About this Structure

1JM7 is a 2 chains structure of sequences from Homo sapiens. Full experimental information is available from OCA.

Reference

Brzovic PS, Rajagopal P, Hoyt DW, King MC, Klevit RE. Structure of a BRCA1-BARD1 heterodimeric RING-RING complex. Nat Struct Biol. 2001 Oct;8(10):833-7. PMID:11573085 doi:10.1038/nsb1001-833

Page seeded by OCA on Tue Feb 17 14:10:38 2009

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1jm7

From Proteopedia

Contents

Solution structure of the BRCA1/BARD1 RING-domain heterodimer

Disease

About this Structure

Reference

Proteopedia Page Contributors and Editors (what is this?)

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