Structural highlights
Function
3NO4_BUNCA Binds and inhibits muscular and neuronal nicotinic acetylcholine receptors (nAChR). Is a reversible antagonist of muscle nAChR (alpha-1-beta-1-delta-epsilon/CHRNA1-CHRNB1-CHRND-CHRNE) (IC(50)=10 nM) and a potent and poorly reversible antagonist of the neuronal alpha-7/CHRNA7 nAChR (IC(50)=50 nM). May exhibit differential affinities for the two binding sites on the muscle nAChR.[1]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
- ↑ Nirthanan S, Charpantier E, Gopalakrishnakone P, Gwee MC, Khoo HE, Cheah LS, Bertrand D, Kini RM. Candoxin, a novel toxin from Bungarus candidus, is a reversible antagonist of muscle (alphabetagammadelta ) but a poorly reversible antagonist of neuronal alpha 7 nicotinic acetylcholine receptors. J Biol Chem. 2002 May 17;277(20):17811-20. PMID:11884390 doi:10.1074/jbc.M111152200
