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1csk
From Proteopedia
| 1csk, resolution 2.50Å () | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Activity: | Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2 | ||||||||
| Domains: | SH3 | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
THE CRYSTAL STRUCTURE OF HUMAN CSKSH3: STRUCTURAL DIVERSITY NEAR THE RT-SRC AND N-SRC LOOP
SH3 domains are modules occurring in diverse proteins, ranging from cytoskeletal proteins to signaling proteins, such as tyrosine kinases. The crystal structure of the SH3 domain of Csk (c-Src specific tyrosine kinase) has been refined at a resolution of 2.5 A, with an R-factor of 22.4%. The structure is very similar to the FynSH3 crystal structure. When comparing CskSH3 and FynSH3 it is seen that the structural and charge differences of the RT-Src loop and the n-Src loop, near the conserved Trp47, correlate with different binding properties of these SH3 domains. The structure comparison suggests that those glycines and acid residues which are very well conserved in the SH3 sequences are important for the stability of the SH3 fold.
The crystal structure of human CskSH3: structural diversity near the RT-Src and n-Src loop., Borchert TV, Mathieu M, Zeelen JP, Courtneidge SA, Wierenga RK, FEBS Lett. 1994 Mar 14;341(1):79-85. PMID:7511113
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1CSK is a 4 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Borchert TV, Mathieu M, Zeelen JP, Courtneidge SA, Wierenga RK. The crystal structure of human CskSH3: structural diversity near the RT-Src and n-Src loop. FEBS Lett. 1994 Mar 14;341(1):79-85. PMID:7511113
Page seeded by OCA on Tue Feb 17 13:39:38 2009
