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1ad6
From Proteopedia
DOMAIN A OF HUMAN RETINOBLASTOMA TUMOR SUPPRESSOR
The pocket region of retinoblastoma tumour suppressor (Rb) is essential for tumour suppressing activity. The Rb pocket is primarily composed of two domains, A and B. We have determined the X-ray crystal structure of domain A (residues 378-562) at 2.3 A resolution. Domain A consists of nine alpha-helices. The overall arrangement of helices in domain A is remarkably similar to the cyclin-box folds found in the crystal structures of cyclin A and TFIIB. This structure, along with domain B which is predicted to be homologous to the cyclin-box, suggests that the Rb pocket is composed of two cyclin-box fold domains. We present the structural/functional features of the Rb pocket, and the potential binding region for cellular or viral proteins within domain A.
Structural similarity between the pocket region of retinoblastoma tumour suppressor and the cyclin-box., Kim HY, Cho Y, Nat Struct Biol. 1997 May;4(5):390-5. PMID:9145110
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1AD6 is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Kim HY, Cho Y. Structural similarity between the pocket region of retinoblastoma tumour suppressor and the cyclin-box. Nat Struct Biol. 1997 May;4(5):390-5. PMID:9145110
Page seeded by OCA on Tue Feb 17 14:33:08 2009
