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1ad5

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1ad5, resolution 2.60Å ()
Ligands: ,
Non-Standard Residues:
Gene: HUMAN HCK (Homo sapiens)
Activity: Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2
Domains: S_TKc, SH2, PTKc_Src_like, SH3
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



SRC FAMILY KINASE HCK-AMP-PNP COMPLEX

Publication Abstract from PubMed

The crystal structure of the haematopoietic cell kinase Hck has been determined at 2.6/2.9 A resolution. Inhibition of enzymatic activity is a consequence of intramolecular interactions of the enzyme's Src-homology domains SH2 and SH3, with concomitant displacement of elements of the catalytic domain. The conformation of the active site has similarities with that of inactive cyclin-dependent protein kinases.

Crystal structure of the Src family tyrosine kinase Hck., Sicheri F, Moarefi I, Kuriyan J, Nature. 1997 Feb 13;385(6617):602-9. PMID:9024658

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

1AD5 is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Sicheri F, Moarefi I, Kuriyan J. Crystal structure of the Src family tyrosine kinase Hck. Nature. 1997 Feb 13;385(6617):602-9. PMID:9024658 doi:10.1038/385602a0

Page seeded by OCA on Tue Feb 17 06:38:45 2009

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