Angiotensin-Converting Enzyme

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Human ACE complex with Zn+2 (grey) and Cl- (yellow) ions (PDB code [[1o8a]])

3D Structures of Angiotensin-Converting Enzyme

Updated on 02-February-2014

1o8a – hANCE - human
2iul, 2iux, 3nxq, 4c2n, 4c2o, 4c2q, 4c2r – hANCE (mutant)
2c6f – hANCE N domain
2c6n - hANCE N domain+lisinopril
1o86 - hANCE +lisinopril
4c2p - hANCE + captopril
2ydm - hANCE + captopril analog
3kbh, 3d0g, 3d0h, 3d0i, 2ajf, 3sci, 3scj, 3sck, 3scl – hANCE 2 fragment+spike glycoprotein
3l3n – hANCE+LISW
3bkk, 3bkl – hANCE+ketone inhibitor
2oc2, 4bxk, 4ca5, 4ca7, 4ca8 - hANCE+phosphinic inhibitor
2xy9, 2xyd - hANCE N domain + phosphinic inhibitor
4ca6 - hANCE N domain (mutant) + phosphinic inhibitor
1uze, 1uzf - hANCE+anti-hypertensive drug
4aph – hANCE + angiotensin II
4apj – hANCE + bradykinin-potentiating peptide B
1r42, 1r4l – hANCE + disordered segment of collectrin homology domain
2xhm – DmANCE+K26 – Drosophila melanogaster
2x8y – DmANCE
2x8z, 2x90, 2x91, 2x92, 2x93, 2x94, 2x95, 2x96, 2x97, 1j36, 1j37, 1j38 – DmANCE+anti-hypertensive drug
3zqz – DmANCE + captopril analog
4aa1 – DmANCE + angiotensin II
4aa2, 4asr – DmANCE + bradykinin-potentiating peptide B
4asq – DmANCE + bradykinin peptide

Additional Resources

For Additional Information, see: Hypertension & Congestive Heart Failure

References

  1. Skeggs, L. T., Dorer, F. E., Kahn, J. R., Lentz, K. E., Levin, M. (1981) Experimental renal hypertension: the discovery of the Renin-Angiotensin system. Soffer, R. eds. Biochemical Regulation of Blood Pressure ,3-38 John Wiley & Sons, Inc. Hoboken.
  2. Hoogwerf BJ, Young JB. The HOPE study. Ramipril lowered cardiovascular risk, but vitamin E did not. Cleve Clin J Med. 2000 Apr;67(4):287-93. PMID:10780101
  3. 3.0 3.1 3.2 Ferrario CM. Role of angiotensin II in cardiovascular disease therapeutic implications of more than a century of research. J Renin Angiotensin Aldosterone Syst. 2006 Mar;7(1):3-14. PMID:17083068
  4. Spyroulias GA, Nikolakopoulou P, Tzakos A, Gerothanassis IP, Magafa V, Manessi-Zoupa E, Cordopatis P. Comparison of the solution structures of angiotensin I & II. Implication for structure-function relationship. Eur J Biochem. 2003 May;270(10):2163-73. PMID:12752436
  5. 5.0 5.1 Brew K. Structure of human ACE gives new insights into inhibitor binding and design. Trends Pharmacol Sci. 2003 Aug;24(8):391-4. PMID:12915047
  6. 6.0 6.1 Sturrock ED, Natesh R, van Rooyen JM, Acharya KR. Structure of angiotensin I-converting enzyme. Cell Mol Life Sci. 2004 Nov;61(21):2677-86. PMID:15549168 doi:10.1007/s00018-004-4239-0
  7. 7.0 7.1 7.2 Weir MR. Effects of renin-angiotensin system inhibition on end-organ protection: can we do better? Clin Ther. 2007 Sep;29(9):1803-24. PMID:18035185 doi:10.1016/j.clinthera.2007.09.019
  8. Henriksen EJ, Jacob S. Modulation of metabolic control by angiotensin converting enzyme (ACE) inhibition. J Cell Physiol. 2003 Jul;196(1):171-9. PMID:12767053 doi:10.1002/jcp.10294
  9. Cole J, Ertoy D, Bernstein KE. Insights derived from ACE knockout mice. J Renin Angiotensin Aldosterone Syst. 2000 Jun;1(2):137-41. PMID:11967804
  10. Junot C, Gonzales MF, Ezan E, Cotton J, Vazeux G, Michaud A, Azizi M, Vassiliou S, Yiotakis A, Corvol P, Dive V. RXP 407, a selective inhibitor of the N-domain of angiotensin I-converting enzyme, blocks in vivo the degradation of hemoregulatory peptide acetyl-Ser-Asp-Lys-Pro with no effect on angiotensin I hydrolysis. J Pharmacol Exp Ther. 2001 May;297(2):606-11. PMID:11303049
  11. 11.0 11.1 11.2 11.3 11.4 11.5 Natesh R, Schwager SL, Sturrock ED, Acharya KR. Crystal structure of the human angiotensin-converting enzyme-lisinopril complex. Nature. 2003 Jan 30;421(6922):551-4. Epub 2003 Jan 19. PMID:12540854 doi:http://dx.doi.org/10.1038/nature01370
  12. Hangauer DG, Monzingo AF, Matthews BW. An interactive computer graphics study of thermolysin-catalyzed peptide cleavage and inhibition by N-carboxymethyl dipeptides. Biochemistry. 1984 Nov 20;23(24):5730-41. PMID:6525336
  13. Jaspard E, Alhenc-Gelas F. Catalytic properties of the two active sites of angiotensin I-converting enzyme on the cell surface. Biochem Biophys Res Commun. 1995 Jun 15;211(2):528-34. PMID:7794265
  14. http://www.yourlawyer.com/topics/overview/ace_inhibitors
  15. Natesh R, Schwager SL, Evans HR, Sturrock ED, Acharya KR. Structural details on the binding of antihypertensive drugs captopril and enalaprilat to human testicular angiotensin I-converting enzyme. Biochemistry. 2004 Jul 13;43(27):8718-24. PMID:15236580 doi:10.1021/bi049480n
  16. 16.0 16.1 Li F. Structural analysis of major species barriers between humans and palm civets for severe acute respiratory syndrome coronavirus infections. J Virol. 2008 Jul;82(14):6984-91. Epub 2008 Apr 30. PMID:18448527 doi:10.1128/JVI.00442-08


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