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1vsa
From Proteopedia
| 1vsa, resolution 3.71Å () | |||||||||
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| Related: | 1gix, 1giy, 2ow8
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Contents |
Crystal Structure of a 70S Ribosome-tRNA Complex Reveals Functional Interactions and Rearrangements. This file, 1VSA, contains the 50S ribosome subunit. 30S ribosome subunit is in the file 2OW8
Our understanding of the mechanism of protein synthesis has undergone rapid progress in recent years as a result of low-resolution X-ray and cryo-EM structures of ribosome functional complexes and high-resolution structures of ribosomal subunits and vacant ribosomes. Here, we present the crystal structure of the Thermus thermophilus 70S ribosome containing a model mRNA and two tRNAs at 3.7 A resolution. Many structural details of the interactions between the ribosome, tRNA, and mRNA in the P and E sites and the ways in which tRNA structure is distorted by its interactions with the ribosome are seen. Differences between the conformations of vacant and tRNA-bound 70S ribosomes suggest an induced fit of the ribosome structure in response to tRNA binding, including significant changes in the peptidyl-transferase catalytic site.
Crystal structure of a 70S ribosome-tRNA complex reveals functional interactions and rearrangements., Korostelev A, Trakhanov S, Laurberg M, Noller HF, Cell. 2006 Sep 22;126(6):1065-77. Epub 2006 Sep 7. PMID:16962654
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1vsa is a 30 chain structure of Ribosomal protein L1, Ribosomal protein L2, Ribosomal protein L3, Ribosomal protein L4, Ribosomal protein L5, Ribosomal protein L6 and Ribosome with sequence from Thermus thermophilus hb27. This structure supersedes the now removed PDB entry 1vs9. Full crystallographic information is available from OCA.
See Also
- Ribosomal protein L1
- Ribosomal protein L2
- Ribosomal protein L3
- Ribosomal protein L4
- Ribosomal protein L5
- Ribosomal protein L6
- Ribosome
Reference
- Korostelev A, Trakhanov S, Laurberg M, Noller HF. Crystal structure of a 70S ribosome-tRNA complex reveals functional interactions and rearrangements. Cell. 2006 Sep 22;126(6):1065-77. Epub 2006 Sep 7. PMID:16962654 doi:10.1016/j.cell.2006.08.032
