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2k4r
From Proteopedia
| 2k4r, 29 NMR models () | |||||||||
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| Gene: | Prss12, nt (Rattus norvegicus) | ||||||||
| Related: | 2k51 | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
NMR solution structure of the neurotrypsin kringle domain
Neurotrypsin is a multidomain protein that serves as a brain-specific serine protease. Here we report the NMR structure of its kringle domain, NT/K. The data analysis was performed with the BACUS (Bayesian analysis of coupled unassigned spins) algorithm. This study presents the first application of BACUS to the structure determination of a (13)C unenriched protein for which no prior experimental 3D structure was available. NT/K adopts the kringle fold, consisting of an antiparallel beta-sheet bridged by an overlapping pair of disulfides. The structure reveals the presence of a surface-exposed left-handed polyproline II helix that is closely packed to the core beta-structure. This feature distinguishes NT/K from other members of the kringle fold and points toward a novel functional role for a kringle domain. Functional divergence among kringle domains is discussed on the basis of their surface and electrostatic characteristics.
NMR Solution Structure of the Neurotrypsin Kringle Domain., Ozhogina OA, Grishaev A, Bominaar EL, Patthy L, Trexler M, Llinas M, Biochemistry. 2008 Oct 29. PMID:18956887
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
2K4R is a 1 chain structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
NMR Solution Structure of the Neurotrypsin Kringle Domain., Ozhogina OA, Grishaev A, Bominaar EL, Patthy L, Trexler M, Llinas M, Biochemistry. 2008 Oct 29. PMID:18956887
Page seeded by OCA on Wed Dec 10 14:51:49 2008
