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Villin
From Proteopedia
| Human Supervillin Headpiece, 2k6n | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Gene: | SVIL (Homo sapiens) | ||||||||
| Related: | 2k6m, 1yu5, 1qzp, 1zv6, 1qqv, 1yu7, 1unc, 1und, 1yu8, 1vii, 2ppz, 1ujs, 1yrf, 1yri, 2jm0, 1wy3, 1wy4 | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Villin (VIL) is an actin-binding protein. It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin[1]. Supervillin (SVIL) contains numerous gelsolin-like domains in its C-terminal and interacts with actin. Advillin (AVIL) is another actin-binding protein in the gelsolin superfamily which is expressed in the peripheral sensory neurons. The images on the left and right correspond to one representative villin structure, i.e. the human supervillin headpiece (2k6n).
3D Structures of Villin
Update December 2011
Supervillin
2k6m, 2k6n – hSVIL headpiece– human – NMR
Villin
3fg7 – hVIL gelsolin domains 4-6
1unc – hVIL headpiece
3iur - hVIL headpiece H2H3 helices+prolyl endopeptidase – Aeromonas punctata
2rjw, 2rjx, 2rjv, 2rjy, 1yu7, 1yu8 – cVIL headpiece (mutant) – chicken
1yu5, 1qqv - cVIL headpiece
3myc, 3mye, 3nkj, 3mya - cVIL headpiece (mutant)
1vii, 2vik, 2vil - cVIL headpiece - NMR
2ppz, 2jm0 - VIL headpiece (mutant) – synthetic – NMR
2f4k, 1wy3, 1wy4, 1yrf, 1yri - VIL fragment (mutant) – synthetic
Advillin
1und – hAVIL headpiece
References
- ↑ Friederich E, Vancompernolle K, Louvard D, Vandekerckhove J. Villin function in the organization of the actin cytoskeleton. Correlation of in vivo effects to its biochemical activities in vitro. J Biol Chem. 1999 Sep 17;274(38):26751-60. PMID:10480879
Proteopedia Page Contributors and Editors (what is this?)
Alexander Berchansky, David Canner, Michal Harel, Jaime Prilusky
