Vascular Endothelial Growth Factor

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Structure of Human VEGF-A dimer, [[1vpf]]

Contents

3D Structures of VEGF

Updated on 21-August-2014

VEGF-A

3bdy, 2qr0 - hVEGF-A + hFab light+heavy chain – human
4kzn - hVEGF-A receptor-binding domain
2fjg, 2fjh - hVEGF-A receptor-binding domain+ hFab light+heavy chain
3p9w - hVEGF-A + hFab heavy chain
1tzh, 1tzi, 1cz8 - hVEGF-A + mFab YADS1 light+heavy chain - mouse
1mkg, 1mkk, 1mjv – hVEGF-A (mutant)
3qtk - hVEGF-A residues 34-135
4glu - hVEGF-A residues 1-102
1kmx - hVEGF-A heparin-binding domain
1vgh, 2vgh - hVEGF-A heparin-binding domain - NMR
1qty, 1flt – hVEGF-A receptor-binding domain + hFMS-like tyrosine
1vpp – hVEGF-A + receptor blocking peptide
1bj1 – hVEGF-A + mFab light+heavy chain fragments
2vpf, 1vpf – hVEGF-A receptor binding domain
1kat - hVEGF-A receptor binding domain + peptide antagonist - NMR
3s1b - hVEGF-A + Mini-Z
3s1k - hVEGF-A + Z-domain
4gln, 4gls - hVEGF-A + D-RFX001
4deq – hVEGF-A /neuropilin-1

VEGF-B

2xac – hVEGF-B receptor binding domain+ hVEGFR domain 2
2vwe – hVEGF-B + mFab light+heavy chain fragments
2c7w – hVEGF-B
3v2a – hVEGF-B + VEGF-A

VEGF-C

2x1w, 2x1x – hVEGF-C VEGF homology domain+ VEGFR-2 domains 2 & 3
4bsk - hVEGF-C VEGF homology domain + VEGFR-3 domains 1 & 2

VEGF-D

2xv7 – hVEGF-D VEGF homology domain

VEGF-E

3v6b – VEGF-E + VEGFR 2 – Orf virus

VEGF-F

1wq8, 1wq9 - VEGF-F – Vipera aspis

Additional Resources

For additional information, see: Cancer

See Also

References

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  2. Ferrara N, Henzel WJ. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun. 1989 Jun 15;161(2):851-8. PMID:2735925
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  7. Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, Fahrig M, Vandenhoeck A, Harpal K, Eberhardt C, Declercq C, Pawling J, Moons L, Collen D, Risau W, Nagy A. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature. 1996 Apr 4;380(6573):435-9. PMID:8602241 doi:http://dx.doi.org/10.1038/380435a0
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  18. http://www.foxbusiness.com/story/markets/industries/technology/roche-increased-avastin-sales-efforts-doubles-force/

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