User:Eran Hodis

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Eran Hodis on the campus of the Weizmann Institute of Science in April of 2008
Eran Hodis on the campus of the Weizmann Institute of Science in April of 2008

I am an MD-PhD student at Harvard Medical School and MIT in Levi Garraway's lab and Aviv Regev's lab. I research and study the somatic genetics of cancer, particularly melanoma. Previously, I studied computational biology as a graduate student at the Weizmann Institute of Science in Eran Segal's lab focusing on transcriptional regulation in yeast. I'm one of the co-creators of Proteopedia -- this website, a 3D encyclopedia of protein structures -- together with Joel L. Sussman and Jaime Prilusky at the Weizmann Institute of Science.

Contact me at firstname_lastname@hms.harvard.edu

Publications

  • Giannakis M, Hodis E, Jasmine Mu X, Yamauchi M, Rosenbluh J, Cibulskis K, Saksena G, Lawrence MS, Qian ZR, Nishihara R, Van Allen EM, Hahn WC, Gabriel SB, Lander ES, Getz G, Ogino S, Fuchs CS, Garraway LA. RNF43 is frequently mutated in colorectal and endometrial cancers. Nat Genet. 2014 Oct 26. doi: 10.1038/ng.3127. PMID:25344691 doi:http://dx.doi.org/10.1038/ng.3127
  • Zeevi D, Lubliner S, Lotan-Pompan M, Hodis E, Vesterman R, Weinberger A, Segal E. Molecular dissection of the genetic mechanisms that underlie expression conservation in orthologous yeast ribosomal promoters. Genome Res. 2014 Oct 7. pii: gr.179259.114. PMID:25294245 doi:http://dx.doi.org/10.1101/gr.179259.114
  • . Comprehensive molecular profiling of lung adenocarcinoma. Nature. 2014 Jul 31;511(7511):543-50. doi: 10.1038/nature13385. Epub 2014 Jul 9. PMID:25079552 doi:http://dx.doi.org/10.1038/nature13385
  • Wagle N, Grabiner BC, Van Allen EM, Hodis E, Jacobus S, Supko JG, Stewart M, Choueiri TK, Gandhi L, Cleary JM, Elfiky AA, Taplin ME, Stack EC, Signoretti S, Loda M, Shapiro GI, Sabatini DM, Lander ES, Gabriel SB, Kantoff PW, Garraway LA, Rosenberg JE. Activating mTOR mutations in a patient with an extraordinary response on a phase I trial of everolimus and pazopanib. Cancer Discov. 2014 May;4(5):546-53. doi: 10.1158/2159-8290.CD-13-0353. Epub 2014, Mar 13. PMID:24625776 doi:http://dx.doi.org/10.1158/2159-8290.CD-13-0353
  • Wagle N, Van Allen EM, Treacy DJ, Frederick DT, Cooper ZA, Taylor-Weiner A, Rosenberg M, Goetz EM, Sullivan RJ, Farlow DN, Friedrich DC, Anderka K, Perrin D, Johannessen CM, McKenna A, Cibulskis K, Kryukov G, Hodis E, Lawrence DP, Fisher S, Getz G, Gabriel SB, Carter SL, Flaherty KT, Wargo JA, Garraway LA. MAP kinase pathway alterations in BRAF-mutant melanoma patients with acquired resistance to combined RAF/MEK inhibition. Cancer Discov. 2014 Jan;4(1):61-8. doi: 10.1158/2159-8290.CD-13-0631. Epub 2013, Nov 21. PMID:24265154 doi:http://dx.doi.org/10.1158/2159-8290.CD-13-0631
  • Van Allen EM, Wagle N, Sucker A, Treacy DJ, Johannessen CM, Goetz EM, Place CS, Taylor-Weiner A, Whittaker S, Kryukov GV, Hodis E, Rosenberg M, McKenna A, Cibulskis K, Farlow D, Zimmer L, Hillen U, Gutzmer R, Goldinger SM, Ugurel S, Gogas HJ, Egberts F, Berking C, Trefzer U, Loquai C, Weide B, Hassel JC, Gabriel SB, Carter SL, Getz G, Garraway LA, Schadendorf D. The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma. Cancer Discov. 2014 Jan;4(1):94-109. doi: 10.1158/2159-8290.CD-13-0617. Epub 2013, Nov 21. PMID:24265153 doi:http://dx.doi.org/10.1158/2159-8290.CD-13-0617
  • Lawrence MS, Stojanov P, Polak P, Kryukov GV, Cibulskis K, Sivachenko A, Carter SL, Stewart C, Mermel CH, Roberts SA, Kiezun A, Hammerman PS, McKenna A, Drier Y, Zou L, Ramos AH, Pugh TJ, Stransky N, Helman E, Kim J, Sougnez C, Ambrogio L, Nickerson E, Shefler E, Cortes ML, Auclair D, Saksena G, Voet D, Noble M, DiCara D, Lin P, Lichtenstein L, Heiman DI, Fennell T, Imielinski M, Hernandez B, Hodis E, Baca S, Dulak AM, Lohr J, Landau DA, Wu CJ, Melendez-Zajgla J, Hidalgo-Miranda A, Koren A, McCarroll SA, Mora J, Lee RS, Crompton B, Onofrio R, Parkin M, Winckler W, Ardlie K, Gabriel SB, Roberts CW, Biegel JA, Stegmaier K, Bass AJ, Garraway LA, Meyerson M, Golub TR, Gordenin DA, Sunyaev S, Lander ES, Getz G. Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature. 2013 Jul 11;499(7457):214-8. doi: 10.1038/nature12213. Epub 2013 Jun 16. PMID:23770567 doi:10.1038/nature12213
  • Huang FW, Hodis E, Xu MJ, Kryukov GV, Chin L, Garraway LA. Highly Recurrent TERT Promoter Mutations in Human Melanoma. Science. 2013 Jan 24. PMID:23348506 doi:10.1126/science.1229259
  • Machado AC, Saleebyan SB, Holmes BT, Karelina M, Tam J, Kim SY, Kim KH, Dror I, Hodis E, Martz E, Compeau PA, Rohs R. Proteopedia: 3D visualization and annotation of transcription factor-DNA readout modes. Biochem Mol Biol Educ. 2012 Nov-Dec;40(6):400-1. doi: 10.1002/bmb.20650. Epub, 2012 Oct 13. PMID:23166030 doi:10.1002/bmb.20650
  • Prilusky J, Hodis E. Proteopedia entry: "Tutorial: How we get the oxygen we breathe". Biochem Mol Biol Educ. 2012 Sep;40(5):339. doi: 10.1002/bmb.20646. PMID:22987558 doi:10.1002/bmb.20646
  • Imielinski M, Berger AH, Hammerman PS, Hernandez B, Pugh TJ, Hodis E, Cho J, Suh J, Capelletti M, Sivachenko A, Sougnez C, Auclair D, Lawrence MS, Stojanov P, Cibulskis K, Choi K, de Waal L, Sharifnia T, Brooks A, Greulich H, Banerji S, Zander T, Seidel D, Leenders F, Ansen S, Ludwig C, Engel-Riedel W, Stoelben E, Wolf J, Goparju C, Thompson K, Winckler W, Kwiatkowski D, Johnson BE, Janne PA, Miller VA, Pao W, Travis WD, Pass HI, Gabriel SB, Lander ES, Thomas RK, Garraway LA, Getz G, Meyerson M. Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing. Cell. 2012 Sep 14;150(6):1107-20. doi: 10.1016/j.cell.2012.08.029. PMID:22980975 doi:10.1016/j.cell.2012.08.029
  • Hodis E, Watson IR, Kryukov GV, Arold ST, Imielinski M, Theurillat JP, Nickerson E, Auclair D, Li L, Place C, Dicara D, Ramos AH, Lawrence MS, Cibulskis K, Sivachenko A, Voet D, Saksena G, Stransky N, Onofrio RC, Winckler W, Ardlie K, Wagle N, Wargo J, Chong K, Morton DL, Stemke-Hale K, Chen G, Noble M, Meyerson M, Ladbury JE, Davies MA, Gershenwald JE, Wagner SN, Hoon DS, Schadendorf D, Lander ES, Gabriel SB, Getz G, Garraway LA, Chin L. A landscape of driver mutations in melanoma. Cell. 2012 Jul 20;150(2):251-63. PMID:22817889 doi:10.1016/j.cell.2012.06.024
  • Berger MF, Hodis E, Heffernan TP, Deribe YL, Lawrence MS, Protopopov A, Ivanova E, Watson IR, Nickerson E, Ghosh P, Zhang H, Zeid R, Ren X, Cibulskis K, Sivachenko AY, Wagle N, Sucker A, Sougnez C, Onofrio R, Ambrogio L, Auclair D, Fennell T, Carter SL, Drier Y, Stojanov P, Singer MA, Voet D, Jing R, Saksena G, Barretina J, Ramos AH, Pugh TJ, Stransky N, Parkin M, Winckler W, Mahan S, Ardlie K, Baldwin J, Wargo J, Schadendorf D, Meyerson M, Gabriel SB, Golub TR, Wagner SN, Lander ES, Getz G, Chin L, Garraway LA. Melanoma genome sequencing reveals frequent PREX2 mutations. Nature. 2012 May 9;485(7399):502-6. doi: 10.1038/nature11071. PMID:22622578 doi:10.1038/nature11071
  • Hodis E, Prilusky J, Sussman JL. Proteopedia: A collaborative, virtual 3D web-resource for protein and biomolecule structure and function. Biochem Mol Biol Educ. 2010 Sep;38(5):341-2. doi: 10.1002/bmb.20431. PMID:21567857 doi:10.1002/bmb.20431
  • Prilusky J, Hodis E, Canner D, Decatur W, Oberholser K, Martz E, Berchanski A, Harel M, Sussman JL. Proteopedia: A status report on the collaborative, 3D web-encyclopedia of proteins and other biomolecules. J Struct Biol. 2011 Apr 23. PMID:21536137 doi:10.1016/j.jsb.2011.04.011
  • Itzkovitz S, Hodis E, Segal E. Overlapping codes within protein-coding sequences. Genome Res. 2010 Sep 14. PMID:20841429 doi:10.1101/gr.105072.110
  • Hodis E, Sussman JL. An encyclopedic effort to make 3D structures easier to understand. Trends Biochem Sci. 2009 Mar;34(3):100-1. Epub 2009 Feb 18. PMID:19230677 doi:10.1016/j.tibs.2009.01.001
  • Sarkar S, Isenberg BC, Hodis E, Leach JB, Desai TA, Wong JY. Fabrication of a layered microstructured polycaprolactone construct for 3-D tissue engineering. J Biomater Sci Polym Ed. 2008;19(10):1347-62. PMID:18854127 doi:10.1163/156856208786052371
  • Hodis E, Prilusky J, Martz E, Silman I, Moult J, Sussman JL. Proteopedia - a scientific 'wiki' bridging the rift between three-dimensional structure and function of biomacromolecules. Genome Biol. 2008;9(8):R121. Epub 2008 Aug 3. PMID:18673581 doi:http://dx.doi.org/10.1186/gb-2008-9-8-r121
  • Hodis E, Schreiber G, Rother K, Sussman JL. eMovie: a storyboard-based tool for making molecular movies. Trends Biochem Sci. 2007 May;32(5):199-204. Epub 2007 Apr 19. PMID:17448663 doi:10.1016/j.tibs.2007.03.008

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Eran Hodis

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