First time at Proteopedia? Click on the green links: they change the 3D image. Click and drag the molecules. Proteopedia is a 3D, interactive encyclopedia of proteins, RNA, DNA and other molecules. With a free user account, you can edit pages in Proteopedia. Visit the Main Page to learn more.
Tripeptidyl peptidase
From Proteopedia
| Tripeptidyl peptidase 2d5l | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Sites: | |||||||||
| Ligands: | |||||||||
| Gene: | PG1361 (Porphyromonas gingivalis W83) | ||||||||
| |||||||||
| |||||||||
| |||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Tripeptidyl peptidase (TPP) is an enzyme which cleaves N-terminal tripeptides from polypeptides. TPP-I functions in lysosomes, TPP-II is part of the ubiquitin-proteasome pathway. The images at the left and at the right correspond to one representative TPP, i.e. the crystal structure of Pro-Tripeptidyl peptidase-IV from Porphyromonas gingivalis (2d5l).
3D Structures of Tripeptidyl peptidase
TPP-I
3ee6 – TPP-I – human
3edy – hTPP-I precursor residues 20-563
TPP-II
3lxu – TPP-II residues 463-770 – Drosophila melanogaster
TPP-IV
2eep – PgPro-TPP-IV+inhibitor – Porphyromonas gingivalis
2d5l - PgPro-TPP-IV
2z3w - PgPro-TPP-IV (mutant)
2z3z, 2dcm - PgPro-TPP-IV (mutant)+inhibitor
