Function
TATA-Binding Protein (TBP) binds to TATA box in DNA and is part of the RNA polymerase II transcription complex. The transcription factor proteins are named TFIIA to TFIIH. TBP is part of TFIID. Its interaction with DNA initiates the DNA strands separation[1]. Called the to represent its thymine-adenine-thymine-adenine-adenine (TATAA) nucleotide motif. See also
Additional information
See: Transcription for additional Proteopedia resources
Relevance
TBP is associated with aggregated proteins in several of the polyglutamine disorders like cerebellar ataxia[2].
Structural highlights
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The interactions of . The DNA duplex is bent in a sharp angle and most interactions are non-polar of hydrophobic[3].
3D Structures of TATA-binding protein
TATA-binding protein 3D structures
