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Crystal Structure of yeast TATA-binding protein, 1tbp

TATA-binding protein, 1tbp
Structural annotation: Resources: CATH : 1Tbpa01, 1Tbpa02, 1Tbpb02, 1Tbpb01 InterPro : Ipr012294, Ipr000814, Ipr012295 Pfam : PF00352 SCOP : d1tbpa2, d1tbpa1, d1tbpb2, d1tbpb1 UniProt : P13393
Functional annotation: Cellular component: transcription factor TFIIIB complex nucleus RNA polymerase I transcription factor complex transcription factor TFIID complex Biological process: transcription initiation from RNA polymerase II promoter transcription initiation from RNA polymerase III promoter transcription from RNA polymerase III promoter transcription transcription from RNA polymerase I promoter regulation of transcription, DNA-dependent transcription from RNA polymerase II promoter Molecular function: protein homodimerization activity protein binding RNA polymerase III transcription factor activity binding RNA polymerase I transcription factor activity RNA polymerase II transcription factor activity DNA binding general RNA polymerase II transcription factor activity DNA bending activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, PDBsum, RCSB
Coordinates:	save as pdb, mmCIF, xml

TATA-Binding Protein (TBP) binds to TATA box in DNA and is part of the RNA polymerase II transcription complex. The transcription factor proteins are named TFIIA to TFIIH. TBP is part of TFIID. Its interaction with DNA initiates the DNA strands separation. The images at the left and at the right correspond to one representative TBP, i.e. the crystal structure of yeast TATA-binding protein (1tbp). See also Transcription and RNA Processing.

3D Structures of TATA-binding protein

Updated December 2011

TBP

2z8u – TBP – Methanococcus janaschii
1pcz – PwTBP - Pyrococcus woesei
1vok – AtTBP - Arabidopsis thaliana
1tbp – yTBP - yeast
1mp9 – TBP – Sulfolobus acidocaldarius
3eik – TBP – Encephalitozoon cuniculi

TBP+DNA TATA

1ytb - yTBP + DNA TATA
1cdw - hTBP core domain+ DNA TATA - human
1tgh - hTBP + DNA TATA
1qn5, 1qn6, 1qn7, 1qn8, 1qn9, 1qna, 1qnb, 1qnc, 1qne, 1qn3, 1qn4, 1vto - AtTBP + DNA TATA

TBP+DNA TATA+TFIIA

1rm1 – yTBP+TFIIA α, β, γ chains+ DNA TATA
1ytf - yTBP+TFIIA + DNA TATA
1nh2 – yTBP C-terminal+TFIIA α, β, γ chains+ DNA TATA
1nvp - hTBP C-terminal+ TFIIA α, β, γ chains+ DNA TATA
1jfi - hTBP C-terminal+ TFIIA NC2+ DNA TATA

TBP+DNA TATA+TFIIB

1ngm - yTBP C-terminal+TFIIIB BRF1 subunit + DNA TATA
1tba – yTBP core domain+TAFII230 fragment - NMR
1c9b - hTBP C-terminal+TFIIBC+adenovirus major late promoter
1vol – AtTBP+hTFIIB+DNA TATA
1ais, 1d3u - PwTBP N-terminal+ TFIIB C-terminal + DNA TATA
1tba – yTBP core domain+TAFII230 fragment - NMR

Additional information

See: Transcription for additional Proteopedia resources

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called the to represent its thymine-adenine-thymine-adenine-adenine (TATAA) nucleotide motif

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