Succinate Dehydrogenase

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Succinate dehydrogenase containing flavoprotein subunit (Sdha) (grey), iron-sulfur subunit (Sdhb) (green), cytochrome B560 subunit (Sdhc) (pink) and cytochrome B small subunit (Sdhd) (yellow), FAD, Fe2S2, Fe4S4 and Fe3S4 complex with protoporphyrin, malonate, benzamide derivative and α-phosphatidyl-β-oleoyl-γ-palmitoyl-phosphatidylethanolamine, 3ae1

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References

  1. Oyedotun KS, Lemire BD. The quaternary structure of the Saccharomyces cerevisiae succinate dehydrogenase. Homology modeling, cofactor docking, and molecular dynamics simulation studies. J Biol Chem. 2004 Mar 5;279(10):9424-31. Epub 2003 Dec 12. PMID:14672929 doi:10.1074/jbc.M311876200
  2. Tomitsuka E, Hirawake H, Goto Y, Taniwaki M, Harada S, Kita K. Direct evidence for two distinct forms of the flavoprotein subunit of human mitochondrial complex II (succinate-ubiquinone reductase). J Biochem. 2003 Aug;134(2):191-5. PMID:12966066
  3. 3.0 3.1 Yankovskaya V, Horsefield R, Tornroth S, Luna-Chavez C, Miyoshi H, Leger C, Byrne B, Cecchini G, Iwata S. Architecture of succinate dehydrogenase and reactive oxygen species generation. Science. 2003 Jan 31;299(5607):700-4. PMID:12560550 doi:10.1126/science.1079605
  4. 4.0 4.1 Horsefield R, Yankovskaya V, Sexton G, Whittingham W, Shiomi K, Omura S, Byrne B, Cecchini G, Iwata S. Structural and computational analysis of the quinone-binding site of complex II (succinate-ubiquinone oxidoreductase): a mechanism of electron transfer and proton conduction during ubiquinone reduction. J Biol Chem. 2006 Mar 17;281(11):7309-16. Epub 2005 Dec 27. PMID:16407191 doi:http://dx.doi.org/10.1074/jbc.M508173200
  5. Kenney WC. The reaction of N-ethylmaleimide at the active site of succinate dehydrogenase. J Biol Chem. 1975 Apr 25;250(8):3089-94. PMID:235539
  6. Voet, Donald, Charlotte W. Pratt, and Judith G. Voet. Fundamentals of Biochemistry: Life at the Molecular Level. 2nd Ed. Hoboken, NJ: Wiley, 2008.
  7. Vinogradov AD, Kotlyar AB, Burov VI, Belikova YO. Regulation of succinate dehydrogenase and tautomerization of oxaloacetate. Adv Enzyme Regul. 1989;28:271-80. PMID:2624174
  8. Boyd AW, Lackmann M. Signals from Eph and ephrin proteins: a developmental tool kit. Sci STKE. 2001 Dec 11;2001(112):re20. PMID:11741094 doi:10.1126/stke.2001.112.re20
  9. 9.0 9.1 9.2 Tran QM, Rothery RA, Maklashina E, Cecchini G, Weiner JH. The quinone binding site in Escherichia coli succinate dehydrogenase is required for electron transfer to the heme b. J Biol Chem. 2006 Oct 27;281(43):32310-7. Epub 2006 Sep 1. PMID:16950775 doi:10.1074/jbc.M607476200
  10. Muller FL, Liu Y, Abdul-Ghani MA, Lustgarten MS, Bhattacharya A, Jang YC, Van Remmen H. High rates of superoxide production in skeletal-muscle mitochondria respiring on both complex I- and complex II-linked substrates. Biochem J. 2008 Jan 15;409(2):491-9. PMID:17916065 doi:10.1042/BJ20071162

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