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Ribosomal protein S6

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Crystal Structure of Ribosomal protein S6 from 2zm6, chain F
Crystal Structure of Ribosomal protein S6 from 2zm6, chain F
Ribosomal protein S6 from 2bvz
Related: 1cqm, 1cqn, 1eg0, 1lou, 1qjh, 1ris, 1twt
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml













Ribosomal protein S6 (RPS6) is one of the 22 proteins which belong to the of the bacterial ribosome. It has a role in regulating translation of RNAs that contain the 5' terminal sequence. It is regulated by ribosomal S6 kinase. The images at the left and at the right correspond to one representative RPS6, i.e. the crystal structure of Ribosomal protein S6 from Thermus thermophilus (2zm6, chain F).




3D Structures of Ribosomal protein S6

Updated on 17-October-2013

RPS6

2kjv – TtRPS6 – NMR - Thermus thermophilus
2kjw – TtRPS6 (mutant)– NMR
2bvz, 1ris, 3zzp – TtRPS6
2bxj, 1cqm, 1cqn, 1qjh, 1lou - TtRPS6 (mutant)
2j5a – RPS6 – Aquifex aeolicus
1vmb – RPS6 – Thermotoga maritima
3r3t – RPS6 – Bacillus anthracis

S6 in small ribosomal subunit

2zm6, 1n36, 1j5e, 3oge, 3ogy, 3ohc, 3ohd, 3ohy, 3oi0, 3oi2, 3oi4, 3oto - TtRPS6 in 30S ribosomal subunit+THX+16S RRNA
2vqe, 2vqf, 2uuc, 2e5l, 2uu9, 2uua, 2uub, 3pyn, 3pyq, 3pys, 3pyu - TtRPS6 in 30S ribosomal subunit+16S RRNA+RNA fragment
3kc4 – EcRPS6 in 30S ribosomal subunit - Escherichia coli
3i1m, 3i1o, 3df1, 3df3, 2vho, 2vhp, 2avy, 2aw7, 1pnx, 1oaq, 3oar, 3ofa, 3ofb, 2ofo, 3ofp, 3ofx, 3ofy, 3or9, 3ora - EcRPS6 in 30S ribosomal subunit+16S RRNA
1i94, 1fka, 3uxs, 3uxt, 4dr1 - TtRPS6 in 30S ribosomal subunit+16S RRNA
4duy, 4duz, 4dv0, 4dv1, 4dv2, 4dv3, 4dv4, 4dv5, 4dv6, 4dv7 - TtRPS6 in 30S ribosomal subunit+16S RRNA (mutant)
4dr4, 4b3m, 4b3r, 4b3s, 4b3t – TtRPS6 in 30S ribosomal subunit+16S RRNA + mRNA
1p87, 1p6g - EcRPS6 in 30S ribosomal subunit+16S RRNA – Cryo-EM
3bbn - RPS6 in 30S ribosomal subunit+16S RRNA – Cryo-EM – spinach

S6 in small + large ribosomal subunit

1ml5 - EcRPS6 in 30S ribosomal subunit+50S ribosomal subunit+THX+chain release factor 2+P-site tRNA+tRNA Phe+mRNA fragment+23S RRNA+5S RRNA+16S RRNA - EM

S6 in small ribosomal subunit+ chain release factor (RF)

3mr8, 3ms0 – TtRPS6 in 30S ribosomal subunit+THX+chain release factor 1+P-site tRNA+mRNA+16S RRNA
3d5a, 3d5c - TtRPS6 in 30S ribosomal subunit+THX+chain release factor 1+P-site tRNA+E-site tRNA+mRNA +16S RRNA
3zvo – TtRPS6 in 30S ribosomal subunit+THX+P-site tRNA Met +mRNA +16S RRNA+chain release factor 3
2b64 - TtRPS6 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA+chain release factor 1
2b9m - TtRPS6 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA+chain release factor 2
2x9r, 2x9t, 2wh1, 2wh3 - TtRPS6 in 30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+mRNA +16S RRNA
3f1e, 3f1g - TtRPS6 in 30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+E-site tRNA +16S RRNA
3uoq - EcRPS6 + 16S RRNA + mRNA + peptide chain release factor
4kfh, 4kfk - TtRPS6 in 30S ribosomal subunit+16S RRNA+ RF-2 + mRNA+ P-site tRNA fMet

S6 in small ribosomal subunit+tRNA+mRNA

2hgi - TtRPS6 in 30S ribosomal subunit+16S RRNA+tRNA Phe+tRNA fMet
4l6k, 4l6m - TtRPS6 in 30S ribosomal subunit+16S RRNA+tRNA Phe+tRNA
2hgp - TtRPS6 in 30S ribosomal subunit+16S RRNA+tRNA Phe+mRNA
3t1h, 3t1y - TtRPS6 in 30S ribosomal subunit+16S RRNA+tRNA Lys +mRNA
3tvf, 3tvg, 3uyd, 3uyf - TtRPS6 in 30S ribosomal subunit+16S RRNA+tRNA Leu + tRNA fMet + mRNA
3zn7, 3znd - TtRPS6 in 30S ribosomal subunit+16S RRNA+A-site tRNA Ile agmatidine + E-site tRNA Ile agmatidine + mRNA
3uz6, 3uz7, 3uzg, 3uzi - TtRPS6 in 30S ribosomal subunit+16S RRNA+tRNA Tyr + tRNA fMet + mRNA
2i2p, 2i2u - EcRPS6 in 30S ribosomal subunit+16S RRNA+tRNA Phe+mRNA
2hgr, 3v6u, 3v6v, 4ej9, 4eja - TtRPS6 in 30S ribosomal subunit+16S RRNA+tRNA Phe+tRNA fMet+mRNA
1yl4 – TtRPS6 in 30S ribosomal subunit+ tRNA Phe+16S RRNA+THRS mRNA operator
1pns - EcRPS6 in 30S ribosomal subunit+ tRNA Phe+16S RRNA+mRNA
3j0u, 3j0v, 3j0x, 3j0z, 3j10 – EcRPS6 in 30S ribosomal subunit+ A-site tRNA + P-site tRNA +16S RRNA+mRNA – Cryo-EM
3j13 – EcRPS6 in 30S ribosomal subunit+ P-site tRNA +16S RRNA+mRNA – Cryo-EM
1xnq, 1xnr - TtRPS6 in 30S ribosomal subunit+THX+mRNA+tRNA anticodon+16S RRNA
4gkj, 4gkk - TtRPS6 in 30S ribosomal subunit +16S RRNA +THX + mRNA + tRNA Met
4jv5, 4jya, 4k0k, 4k0l - TtRPS6 in 30S ribosomal subunit +16S RRNA +THX + mRNA + ASL-tRNA

S6 in small ribosomal subunit+A-site tRNA

2uxd , 2uxc - TtRPS6 in 30S ribosomal subunit+THX+A-site mRNA CGGG+tRNA anticodon+16S RRNA
1n32, 1n33 - TtRPS6 in 30S ribosomal subunit+THX+A-site mRNA fragment+tRNA anticodon+16S RRNA
1n34 - TtRPS6 in 30S ribosomal subunit+THX+A-site mRNA fragment +16S RRNA
1xmo, 1xmq - TtRPS6 in 30S ribosomal subunit+THX+A-site mRNA+tRNA anticodon+16S RRNA
2uxb - TtRPS6 in 30S ribosomal subunit+THX+A-site mRNA GGGU+tRNA anticodon+16S RRNA

S6 in small ribosomal subunit+P-site tRNA

3i8g - TtRPS6 in 30S ribosomal subunit+P-site tRNA+mRNA +16S RRNA
3i8h, 3i9b, 3i9d - TtRPS6 in 30S ribosomal subunit+THX+P-site tRNA+mRNA +16S RRNA
1ibk - TtRPS6 in 30S ribosomal subunit+THX+P-site mRNA fragment +16S RRNA
2wwl - EcRPS6 in 30S ribosomal subunit+Poly-Ala chain+P-site tRNA+mRNA +16S RRNA - Escherichia coli
3i1q - EcRPS6 in 30S ribosomal subunit+P-site tRNA hairpin+mRNA
3i1s, 3i1z, 3i21 - EcRPS6 in 30S ribosomal subunit+P-site tRNA hairpin+mRNA +16S RNA

S6 in small ribosomal subunit+A-site tRNA+P-site tRNA

1ibl, 1ibm - TtRPS6 in 30S ribosomal subunit+THX+A-site mRNA fragment+P-site mRNA fragment+tRNA anticodon+16S RRNA

S6 in small ribosomal subunit+P-site tRNA+E-site tRNA

2ow8 - TtRPS6 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA+mRNA +16S RRNA
2b9o - TtRPS6 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA
2qnh - TtRPS6 in 30S ribosomal subunit+THX+P-site tRNA+E-site tRNA+mRNA +16S RRNA
2wdg, 2wdh, 2wdk, 2wdm - TtRPS6 in 30S ribosomal subunit+THX+P-site tRNA+E-site tRNA+mRNA +16S RRNA+tRNA Phe

S6 in small ribosomal subunit+A-site tRNA+P-site tRNA+E-site tRNA

2gy9, 2gyb - EcRPS6 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA – Cryo-EM
1jgo, 1jgp, 1jgq, 1gix - TtRPS6 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+tRNA Phe+mRNA +16S RRNA
4k0p - TtRPS6 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA +mRNA +16S RRNA
3e1a, 3e1c - EcRPS6 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA

S6 in small ribosomal subunit + antibiotics

1i95, 1i97, 2hhh, 2f4v, 3knn, 4dr2, 4dr3 - TtRPS6 in 30S ribosomal subunit+16S RRNA+antibiotic
1hnw, 1hnx, 1hnz, 1fjg, 4aqy, 4dr5, 4dr6, 4dr7, 4khp - TtRPS6 in 30S ribosomal subunit+16S RRNA+mRNA fragment+antibiotic
2qbb, 2qb9, 1vs5, 1vs7, 2qan, 2qal, 2qou, 2qow, 2qoy, 2qp0, 2z4k, 2z4m, 3oaq, 3ofo - EcRPS6 in 30S ribosomal subunit+16S RRNA+antibiotic
3sfs – EcRPS6 in 30S ribosomal subunit+16S RRNA+ mRNA + RF-3 + antibiotic
4gaq, 4gas – EcRPS6 in 30S ribosomal subunit+16S RRNA+ mRNA + antibiotic
2j00, 2j02 - TtRPS6 in 30S ribosomal subunit+16S RRNA+paromomycin+P-site tRNA fMet+E-site tRNA Phe+mRNA
3knl, 3knm, 3knj, 3knh - TtRPS6 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA+ antibiotics
3uz3, 3uz4 - TtRPS6 in 30S ribosomal subunit+16S RRNA+tRNA Leu + tRNA fMet + mRNA + paromomycin
4g5k, 4g5m, 4g5t, 4g5v - TtRPS6 in 30S ribosomal subunit+16S RRNA + tRNA fMet + mRNA + antibiotics
3uzl, 3uzm - TtRPS6 in 30S ribosomal subunit+16S RRNA+tRNA Tyr + tRNA fMet + mRNA + paromomycin

S6 in small ribosomal subunit + ribosome recycling factor

2qbd, 2qbf - EcRPS6 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor
3r8n, 3r8o, 4gd1, 4gd2 – EcRPS6 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor + mRNA + tRNA
2qbh, 2qbj - EcRPS6 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor+gentamicin
2v46, 2v48 - TtRPS6 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor+P-site tRNA Phe+mRNA+tRNA fMet

S6 in small ribosomal subunit + elongation factor

2wri, 2wrk, 2xsy, 2xuy - TtRPS6 in 30S ribosomal subunit+THX+P-site tRNA+mRNA +16S RRNA+elongation factor G
2wrn, 2wrq - TtRPS6 in 30S ribosomal subunit+THX+A-site tRNA+mRNA +16S RRNA+elongation factor TU-4
3fic - TtRPS6 in 30S ribosomal subunit+THX+A-site tRNA+P-site tRNA+E-site tRNA+mRNA codon+16S RRNA+elongation factor TU-A
4abr - TtRPS6 in 30S ribosomal subunit+THX + E/P-site tRNA fMet +mRNA codon+16S RRNA+elongation factor TU
3izv – EcRPS6 in 30S ribosomal subunit+A/T-site tRNA Phe +16S RRNA+elongation factor TU
3j18 - EcRPS6 in 30S ribosomal subunit+A/T-site tRNA Phe +16S RRNA+ mRNA + SSRA-binding protein + formyl-Met specific initiator tRNA + elongation factor G – Cryo-EM
3izw – EcRPS6 in 30S ribosomal subunit+A-site tRNA Phe +mRNA +16S RRNA+elongation factor TU
2y0u, 2y0w, 2y0y, 2y10, 2y12, 2y14, 2y16, 2y18 - TtRPS6 in 30S subunit+THX+A-site tRNA+E-site tRNA+mRNA codon+elongation factor TU
3fih - EcRPS6 in 30S ribosomal subunit+A-site tRNA Phe+P-site tRNA+mRNA +16S RRNA+elongation factor TU
3huw, 3huy - TtRPS6 in 30S ribosomal subunit+THX+tRNA-Met+mRNA +16S RRNA+elongation factor P
2xqd – TtRPS6 in 30S ribosomal subunit+THX+E-site tRNA+mRNA +16S RRNA+elongation factor TU-B
4b8f, 4b8h - TtRPS6 in 30S ribosomal subunit+THX+RNA+mRNA +16S RRNA+elongation factor G
4btc, 4kdg, 4kdj - TtRPS6 in 30S ribosomal subunit+THX+RNA +16S RRNA+elongation factor G
4juw - TtRPS6 in 30S ribosomal subunit+THX+ tRNA Phe +16S RRNA + mRNA +elongation factor G
4kbt, 4kbv, 4kcy, 4kd0, 4kd8, 4kda - TtRPS6 in 30S ribosomal subunit+THX+ tRNA Met +16S RRNA + mRNA + viomycin + elongation factor G
4kiy, 4kj0, 4kj2, 4kj4, 4kj6, 4kj8, 4kja, 4kjc - EcRPS6 in 30S ribosomal subunit +16S RRNA + viomycin + elongation factor G

S6 in small ribosomal subunit + translation initiation factor

1i96 - TtRPS6 in 30S ribosomal subunit+THX+IF3+16S RRNA
1hr0 - TtRPS6 in 30S ribosomal subunit+THX+IF+16S RRNA

S6 in small ribosomal subunit + various proteins

3kiq, 3kis, 3kiu, 3kix - TtRPS6 in 30S ribosomal subunit+toxin RelE+16S RRNA
1voq, 1vos , 1vov, 1vox, 1voz - EcRPS6 in 30S ribosomal subunit+protein Y+16S RRNA
3j36 - EcRPS6 in 30S ribosomal subunit+ tetracycline resistance protein +16S RRNA + mRNA + P-tRNA – Cryo-EM
3iy8 – EcRPS6+EcRPS5+EcRPS8+EcRPS9+EcRPS11+EcRPS12+EcRPS15+EcRPS16+EcRPS17+EcRPS18+Leishmania taretolae small subunit
2xfz, 2xg1 – TtRPS6 in 30S ribosomal subunit+colicin E3+E-site tRNA+mRNA+16S RRNA
4dh9, 4dhb - TtRPS6 in 30S ribosomal subunit +16S RRNA+mRNA+P-site tRNA fMet +THX + YAEJ
3j00 – EcRPS6 + 16S RRNA + FTSQ + apolipoprotein A-I
2ykr – EcRPS6 + 16S RRNA + GMPPNP + GTPase RSGA
4a2i – EcRPS6 + 16S RRNA + GTPase RSGA – Cryo EM
4adv - EcRPS6 + 16S RRNA + methyltransferase – Cryo EM
3v22, 3v24, 3v26, 3v28 – TtRPS6 in 30S ribosomal subunit +16S RRNA +THX + modulation factor
3v2c, 3v2e – TtRPS6 in 30S ribosomal subunit +16S RRNA +THX + ribosome-associated inhibitor
3u5c, 3u5g - yRPS6 in 40S ribosomal subunit+ RACK1 + suppressor protein SMT1

S6 in part of small ribosomal subunit

1qd7 – TtRPS6+TtRPS4+TtRPS5+TtRPS7+TtRPS8+TtRPS15+TtRPS17+TtRPS20+16S RRNA fragment
1g1x - TtRPS6+TtRPS15+TtRPS18+16S RRNA fragment
3j16 – yRPS6 + yRPS24 + yRPS30 + yRPL6 + yRPL10 + yRPL11 + 18S RRNA + 28SRRNA + P-site tRNA – Cryo EM

S6 in small 40S ribosomal subunit

3j38 - RPS6 in 40S ribosomal subunit + EF-2 + guanine nucleotide-binding protein – Drosophila melanogaster – Cryo-EM
3j3a - RPS6 in 40S ribosomal subunit + EF-2 + guanine nucleotide-binding protein – human – Cryo-EM
4kzx - rRPS6 in 40S ribosomal subunit+ RACK1 + EIF1 – rabbit – Cryo-EM
4kzy - rRPS6 in 40S ribosomal subunit+ RACK1 + EIF1 + EIF1A – Cryo-EM
4kzz - rRPS6 in 40S ribosomal subunit+ RACK1 + EIF1A + initiator tRNA – Cryo-EM
3zey - rRPS6 in 40S ribosomal subunit – Trypanosoma brucei – Cryo-EM
4bpe, 4bpn, 4bpo, 4bpp - rRPS6 in 40S ribosomal subunit+ 18SRRNA + EIF1 + EIF1A – Tetrahymena thermophila

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