Ribosomal protein L5

From Proteopedia

Se-Met ribosomal protein L5 complex with 5S RNA from Thermus thermophilus, Mg+2 (green) and K+ (purple) ions (PDB code 1mji) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Ribosomal protein L5 (RPL5) is one of the 34 proteins which belong to the of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. It is known to bind to the 5S RRNA from the large subunit. In the archaea like in Haloarcula marismortui, the L5 is called L5P (RPL5P). The 3D structure of the Ribosomal protein L5 complex with 5S RNA from Thermus thermophilus, (PDB code 1mji) is shown to the right[1]. Relevance Mutations in RPL5 are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients[2].

3D Structures of Ribosomal protein L5

Updated on 27-February-2022

References

1. ↑ Perederina A, Nevskaya N, Nikonov O, Nikulin A, Dumas P, Yao M, Tanaka I, Garber M, Gongadze G, Nikonov S. Detailed analysis of RNA-protein interactions within the bacterial ribosomal protein L5/5S rRNA complex. RNA. 2002 Dec;8(12):1548-57. PMID:12515387
2. ↑ Gazda HT, Sheen MR, Vlachos A, Choesmel V, O'Donohue MF, Schneider H, Darras N, Hasman C, Sieff CA, Newburger PE, Ball SE, Niewiadomska E, Matysiak M, Zaucha JM, Glader B, Niemeyer C, Meerpohl JJ, Atsidaftos E, Lipton JM, Gleizes PE, Beggs AH. Ribosomal protein L5 and L11 mutations are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients. Am J Hum Genet. 2008 Dec;83(6):769-80. PMID:19061985 doi:S0002-9297(08)00589-2