Function
Rho guanine nucleotide exchange factor (GEF) stimulate the exchange of the inactive GDP-bound GTPase to its active GTP-bound form. Binding of GEF to GDP-GTPase catalyzes the dissociation of GDP from the protein[1]. GEF domains include the catalytic DH/PH (Dbl Homology/Pleckstrin Homology) domain; the CH (Calponin Homology) domain is believed to be involved in calcium regulation; the SH3 domain interacts with proline-rich sequences.
- Rho guanine nucleotide exchange factor 1 binds to G proteins and stimulate Rho-dependent signals.
- Rho guanine nucleotide exchange factor 6 acts on RAC1.
Disease
Increased GEF activity is involved in cancer cell proliferation by affecting Rho GTPases [2].
3D Structures of Rho guanine nucleotide exchange factor
Rho guanine nucleotide exchange factor 3D structures
