Prion

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Human major prion protein complex with Cd+ (pink) and Cl- (green) ions (PDB code 3haf)

Contents

3D structures of prion

Updated on 20-August-2014

PrP short polypeptides

3nve – ShPrP residues 138 -143 – Syrian hamster
2kkg - PrP residues 23 -106 – Golden hamster - NMR
3nvf – hPrP residues 138 -143 – human
2ol9 - hPrP residues 170 – 175
3nhc, 3nhd, 3md4, 3md5 - hPrP residues 127 – 132
2iv5 - hPrP residues 173 -195 – NMR
1oei - hPrP residues 61 - 84 – NMR
1oeh - hPrP residues 61 - 68 – NMR
2lbg - hPrP residues 110 - 136 – NMR
2iv6 - hPrP residues 173 -195 (mutant) – NMR
2iv4 - hPrP residues 180 -195 – NMR
4e1h, 4e1i - hPrP residues 177 -182 + 211-216
3nvg, 3nvh - mPrP residues 138 -143 – mouse
1skh - bPrP residues 1 – 30 - bovine
3fva - ePrP residues 173 -178 – Elk
1s4t - sPrP residues 135 – 155 – sheep – NMR
1m25 - sPrP residues 152 – 156 – NMR
1g04 - sPrP residues 145 – 169 – NMR
2rmv, 2rmw - sPrP residues 142 – 166 (mutant) – NMR

PrP

3o79 – rPrP C-terminal – rabbit
4hls, 4hmm, 4hmr- rPrP C-terminal (mutant)
2fj3 - rPrP C-terminal – NMR
2joh, 2jom - rPrP C-terminal (mutant) – NMR
1xyw – ePrP C terminal - NMR
2ku4 - PrP C-terminal – horse
3fva - ePrP C-terminal – NMR
2kfl - PrP C-terminal – Wallaby – NMR
2k56 - PrP C-terminal – Vole – NMR
2ktm – sPrP residues 167-234 H2H3 domain (mutant) – NMR
1xyu, 1y2s - sPrP C-terminal – NMR
1uw3 - sPrP C-terminal
3haf, 3hak, 3hj5, 1i4m - hPrP C-terminal
1hjm, 1hjn, 2kun – hPrP C-terminal – NMR
1h0l, 1fkc, 2k1d, 1fo7, 1e1s, 1e1g, 1e1j, 1e1p, 1e1u, 1e1w, 1qlx, 1qlz, 1qm0, 1qm1, 1qm2, 1qm3, 1qlz, 1qm0, 1qm1, 2lej- hPrP C-terminal (mutant) - NMR
3heq, 3her, 3hes, 3hjx - hPrP C-terminal (mutant)
2lft, 2lsb, 2m8t - hPrP residues 90 -231 – NMR
2lv1 - hPrP residues 90 -231 (mutant) – NMR
2lsb - hPrP residues 120 -230 + antibody
2ku5, 2ku6, 2kfm, 2kfo, 2k5o, 1y16, 1y15 - mPrP C-terminal (mutant) - NMR
1xyx - mPrP C-terminal - NMR
2l1k, 2l1d, 2l1e, 2l40 - mPrP C terminal (mutant) – NMR
1ag2, 2l1h, 2l39 - mPrP C terminal - NMR
1u3m – PrP C-terminal – chicken – NMR
1u5l - PrP C-terminal – turtle – NMR
1xu0 - PrP C-terminal – frog – NMR
1xyj - PrP C-terminal – cat – NMR
1xyk - PrP C-terminal – dog – NMR
1xyq - PrP C-terminal – pig – NMR
1dwy, 1dx0, 1dx1 - bPrP C-terminal – NMR
1dwz - bPrP C-terminal (mutant) - NMR
1b10 - ShPrP C-terminal – NMR
2lh8 - ShPrP C-terminal + thiamine – NMR

Yeast prions

2onx, 2olx – Sup35 residues 8 - 11 – yeast
2omm, 1yjo, 1yjp – Sup35 residues 7 – 13
1jzr, 1k0a, 1k0b, 1k0c, 1k0d – Ure2p + glutathione derivartive
1g6w, 1g6y – Ure2p globular domain
1hqo – Ure2p nitrogen regulation fragment

PrP+antibody

2w9e, 4h88 - hPrP C-terminal + anti-PrP antibody
2lsb, 4dgi - hPrP residues 120 -230 + antibody
4j8r - mPrP residues 67-82 + antibody
4ma7, 4ma8 - mPrP residues 116 - 229 + antibody
4n9o, 4kml - hPrP 90-231 + nanobody
2hh0 - bPrP peptide epitope + anti-PrP antibody
1cu4 - ShPrP peptide epitope + anti-PrP antibody
1tpx, 1tqb, 1tqc - sPrP C-terminal + anti-PrP antibody

HET-S from Podospora anserine

2kj3, 2rnm – HET-S C-terminal – NMR
2wvn, 2wvo - HET-S N-terminal
2wvq - HET-S N-terminal (mutant)

  1. Cong X, Bongarzone S, Giachin G, Rossetti G, Carloni P, Legname G. Dominant-negative effects in prion diseases: insights from molecular dynamics simulations on mouse prion protein chimeras. J Biomol Struct Dyn. 2012 Aug 30. PMID:22934595 doi:10.1080/07391102.2012.712477

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Michal Harel, Alexander Berchansky

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