Phosphofructokinase (PFK)

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PFK: R-state Biological tetramer complex with fructose-6-phosphate, ADP and Mg+2 ion; generated from 4pfk by QPS

Contents

3D structures of PFK

Updated on 20-August-2014

Phosphofructokinase

3o8l, 3o8n – PFK – rabbit
3o8o – PFK – yeast
2pfk – EcPFK-1 – Escherichia coli
3umo – EcPFK-2
2hig – TbPFK – Trypanosoma brucei
1zxx – PFK – Lactobacillus delbrueckii
6pfk, 3pfk, 3u39 – GsPFK – Geobacillus stearothermophilus
4i36 – GsPFK (mutant)
1u2x – PhPFK – Pyrococcus horikoshii
3hic – LiPFK – Listeria innocua
3opy – PFK – Pichia pastoris
4du5 – PFKB - Polaromonas
4a3s – PFK – Bacillus subtilis

PFK complexes

3n1c – EcPFK-2 + fructose-6-phosphate
3cqd, 3ump – EcPFK-2 + ATP
3uqe - EcPFK2 (mutant) + ATP
3uqd – EcPFK2 + fructose-1,6-bisphosphate + ATP
1pfk – EcPFK + fructose-1,6-bisphosphate + ADP
3drw – PhPFK (mutant) + ADP
3f5m – TbPFK + ATP
3ie7 – LiPFK + ATP
1mto - GsPFK (mutant) + fructose-6-phosphate
4i4i, 4i7e - GsPFK (mutant) + phosphoenolpyruvate
6pfk – GsPFK + phosphoglycolic acid
4pfk - GsPFK + fructose-6-phosphate + ADP

Pyrophosphate-dependent PFK

1kzh – PFK – Borrelia burgdorferi
3k2q – PFK – Marinobacter aquaeolei
3hno – PFK – Nitrosospira multiformis

Additional Resources

For additional information, see: Carbohydrate Metabolism

References

  1. Schirmer T, Evans PR. Structural basis of the allosteric behaviour of phosphofructokinase. Nature. 1990 Jan 11;343(6254):140-5. PMID:2136935 doi:http://dx.doi.org/10.1038/343140a0
  2. Voet, Donald, Judith G. Voet, and Charlotte W. Pratt. Fundamentals of Biochemistry: Life at the Molecular Level. Hoboken, NJ: Wiley, 2008. Print.
  3. Evans PR, Farrants GW, Hudson PJ. Phosphofructokinase: structure and control. Philos Trans R Soc Lond B Biol Sci. 1981 Jun 26;293(1063):53-62. PMID:6115424
  4. http://www.nature.com/nature/journal/v327/n6121/abs/327437a0.html
  5. Voet, Donald, Judith G. Voet, and Charlotte W. Pratt. Fundamentals of Biochemistry: Life at the Molecular Level. Hoboken, NJ: Wiley, 2008. Print.
  6. PubMed:2136935
  7. Campos G, Guixe V, Babul J. Kinetic mechanism of phosphofructokinase-2 from Escherichia coli. A mutant enzyme with a different mechanism. J Biol Chem. 1984 May 25;259(10):6147-52. PMID:6233271
  8. Voet, Donald, Judith G. Voet, and Charlotte W. Pratt. Fundamentals of Biochemistry: Life at the Molecular Level. Hoboken, NJ: Wiley, 2008. Print.
  9. Voet, Donald, Judith G. Voet, and Charlotte W. Pratt. Fundamentals of Biochemistry: Life at the Molecular Level. Hoboken, NJ: Wiley, 2008. Print.
  10. Voet, Donald, Judith G. Voet, and Charlotte W. Pratt. Fundamentals of Biochemistry: Life at the Molecular Level. Hoboken, NJ: Wiley, 2008. Print.
  11. PubMed:2136935
  12. Voet, Donald, Judith G. Voet, and Charlotte W. Pratt. Fundamentals of Biochemistry: Life at the Molecular Level. Hoboken, NJ: Wiley, 2008. Print.
  13. Campos G, Guixe V, Babul J. Kinetic mechanism of phosphofructokinase-2 from Escherichia coli. A mutant enzyme with a different mechanism. J Biol Chem. 1984 May 25;259(10):6147-52. PMID:6233271
  14. Kimmel JL, Reinhart GD. Reevaluation of the accepted allosteric mechanism of phosphofructokinase from Bacillus stearothermophilus. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):3844-9. PMID:10759544 doi:10.1073/pnas.050588097

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