NADPH-Cytochrome P450 Reductase

From Proteopedia

Human NADPH-Cytochrome P450 reductase FMN-binding and FAD/NADPH domains complex with FMN, FAD, NADP and Ca+2 ion (green) (PDB entry 3qe2) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Disease 3 Structural highlights Function NADPH-Cytochrome P450 Reductase (P450r) or NADPH cytochrome P450 oxidoreductase is the electron donor for several oxygenase enzymes including Cytochrome P450[1]. See also NADPH Cytochrome P450 Oxidoreductase. Disease Mutations in P450r resulting in its deficiency are observed in many steroid metabolizing diseases and in skeletal malformation[2]. Structural highlights P450r electron transfer cofactors: [3]. . Water molecule are shown as red spheres. . . . . .

3D Structures of NADPH-Cytochrome P450 Reductase

Updated on 11-July-2023

References

1. ↑ Hamdane D, Xia C, Im SC, Zhang H, Kim JJ, Waskell L. Structure and function of an NADPH-cytochrome P450 oxidoreductase in an open conformation capable of reducing cytochrome P450. J Biol Chem. 2009 Apr 24;284(17):11374-84. Epub 2009 Jan 26. PMID:19171935 doi:10.1074/jbc.M807868200
2. ↑ Pandey AV, Fluck CE. NADPH P450 oxidoreductase: structure, function, and pathology of diseases. Pharmacol Ther. 2013 May;138(2):229-54. doi: 10.1016/j.pharmthera.2013.01.010., Epub 2013 Jan 24. PMID:23353702 doi:http://dx.doi.org/10.1016/j.pharmthera.2013.01.010
3. ↑ Xia C, Panda SP, Marohnic CC, Martasek P, Masters BS, Kim JJ. Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency. Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13486-91. Epub 2011 Aug 1. PMID:21808038 doi:10.1073/pnas.1106632108