MAP kinase phosphatase

From Proteopedia

MAP kinase phosphatase 3 (PDB code 1hzm) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function MAP kinase phosphatase (MKP) or Dual specificity phosphatase (DUSP) are phosphatases which reverse the activation of MAP kinases by dephosphorylating tyrosine or threonine residues[1]. MKP-4 and MKP-5 are localized in the nucleus and cytosole MKP-6, MKP-7 and MKP-3 are localized in the nucleus Relevance DUSP is implicated in the initiation and development of cancer[2].

3D Structures of MAP kinase phosphatase

Updated on 27-June-2023

3ezz – hMKP-2 (mutant) or DUSP-HVH2 - human
2hcm – mDUSP
1m3g – hMKP-PAC-1 catalytic domain (mutant) - NMR
2g6z – hMKP-3
1hzm - hMKP-3 or DUSP-5
1mkp - hMKP-3 or DUSP-5 (mutant)
3lj8 – hMKP-4
4jmk – hDUSP-8 (mutant)
2ouc, 2oud, 1zzw, 7y4c - hMKP-5 or DUSP-10
7y4b, 7y4d, 7y4e – hMKP-5 (mutant)
6mc1, 7u4o, 7u4r, 7umu, 7umv, 7un0, 7un4 – hMKP-5 + inhibitor
3tg1 – hMKP-5 + MAP kinase 14
4jmj – hDUSP-11 catalytic domain (mutant)
2wgp – hMKP-6 or DUSP-14
1yz4 – hDUSP-15 catalytic domain (mutant)
2vsw, 3tg3 - hMKP-7 or DUSP-16
4yr8 – hMKP-7 + MAPK8
4d3p, 4d3q, 4d3r – hDUSP-19 (mutant)
4woh – hDUSP-22 (mutant) + nitrophenolphosphate
2img – hDUSP-23 + malate
5gtj, 4b04, 4hrf – hDUSP-26 catalytic domain (mutant)

References

1. ↑ Boutros T, Chevet E, Metrakos P. Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: roles in cell growth, death, and cancer. Pharmacol Rev. 2008 Sep;60(3):261-310. doi: 10.1124/pr.107.00106. PMID:18922965 doi:http://dx.doi.org/10.1124/pr.107.00106
2. ↑ Keyse SM. Dual-specificity MAP kinase phosphatases (MKPs) and cancer. Cancer Metastasis Rev. 2008 Jun;27(2):253-61. doi: 10.1007/s10555-008-9123-1. PMID:18330678 doi:http://dx.doi.org/10.1007/s10555-008-9123-1