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From Proteopedia

Mouse α-lactalbumin complex with UDP-glucose and β-1,3-galactosyl transferase, 1o23
Sites:	, , , , , , , , , and
Ligands:	, , , , ,
Gene:	LALBA (Mus musculus), BETA1,4-GALACTOSYLTRANSFERASE (Bos taurus)
Activity:	N-acetyllactosamine synthase, with EC number 2.4.1.90
Structural annotation: Resources: CATH : 1O23A00, 1O23B00, 1O23C00, 1O23D00 InterPro : Ipr000545, Ipr001916, Ipr003859 Pfam : PF00062, PF02709 SCOP : d1o23a_, d1o23b_, d1o23c_, d1o23d_ UniProt : P29752, P08037
Functional annotation: Cellular component: extracellular region extracellular space external side of plasma membrane basolateral plasma membrane integral to membrane Golgi apparatus glycocalyx brush border membrane Golgi trans cisterna plasma membrane desmosome membrane cell surface Biological process: lactose biosynthetic process acute inflammatory response negative regulation of cell proliferation oligosaccharide biosynthetic process leukocyte migration glycoprotein biosynthetic process angiogenesis involved in wound healing penetration of zona pellucida cell adhesion branching morphogenesis of a tube regulation of acrosome reaction regulation of cell motility development of secondary sexual characteristics extracellular matrix organization and biogenesis protein amino acid terminal N-glycosylation galactose metabolic process binding of sperm to zona pellucida carbohydrate metabolic process positive regulation of apoptosis involved in mammary gland involution positive regulation of epithelial cell proliferation involved in wound healing mammary gland development epithelial cell development Molecular function: lactose synthase activity calcium ion binding transferase activity, transferring glycosyl groups cytoskeletal protein binding UDP-galactosyltransferase activity manganese ion binding metal ion binding galactosyltransferase activity N-acetyllactosamine synthase activity transferase activity beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, PDBsum, RCSB
Coordinates:	save as pdb, mmCIF, xml

Lactalbumin (LCA) is the albumin contained in milk and obtained from whey. It has α (LCAa) and β (LCAb) forms. LCAa is the regulatory subunit of the lactose synthase heterodimer which produces lactose by transferring galactose moieties to glucose. LCAa is tested as a target for potential breast cancer vaccine. LCAb is the major whey protein of cow and sheep milk. LCAb is the target of testing for the presence of milk as an allergen.

3D Structures of lactalbumin

Updated December 2011

1alc – LCAa – baboon

1hml, 1b9o – hLCAa –human

1a4v – hLCAa Ca-binding domain
1cb3 – hLCAa residues 1-13 - NMR
1hfx – LCAa – guinea pig

1hfy – gLCAa – goat

1hmk, 1fkq, 1fkv – gLCAa (mutant)

1f6r, 1f6s, 2g4n – bLCAa - bovine

1hfz – bLCAa (mutant)

LCAa complexes

1nf5 – mLCAa + β-1,4-galactosyl transferase + glucose – mouse

1nhe – mLCAa + β-1,4-galactosyl transferase + UDP

1nkh – mLCAa + β-1,4-galactosyl transferase + UDP + Mn

1nmm – mLCAa + β-1,4-galactosyl transferase (mutant)

1nqi - mLCAa + β-1,4-galactosyl transferase

1nwg - mLCAa + β-1,4-galactosyl transferase + butanoyl-glucosamine

1o23 - mLCAa + β-1,4-galactosyl transferase + UDP-glucose

1oqm - mLCAa + β-1,4-galactosyl transferase + UDP-acetyl-galactosamine

1pzy - mLCAa (mutant) + β-1,4-galactosyl transferase + acetyl-glucosamine + UDP + Mn

1yro - mLCAa + β-1,4-galactosyl transferase + UDP-galactose + Mn

1fyc - mLCAa (mutant) + β-1,4-galactosyl transferase + UDP-galactose + Ca

2fyd, 2fyc - mLCAa (mutant) + β-1,4-galactosyl transferase + glucose + UDP-acetylgalactosamine + Mn