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The Structure and Mechanism of Hexokinase

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Structure of human Glucokinase complex with sulfate and Na+ ion 1v4t

3D structures of hexokinase


Additional Resources

For additional information, see: Carbohydrate Metabolism


  1. Pollard-Knight D, Cornish-Bowden A. Mechanism of liver glucokinase. Mol Cell Biochem. 1982 Apr 30;44(2):71-80. PMID:7048063
  2. Koshland D. Induced Fit and Hexokinase.Fig.7 Active Site of Glucokinase/Hexokinase.2010; [1]
  3. Kitto B.G, Caras J., Caras P. Interactive Concepts in Biochemistry. Structural Tutorials.2008; Chp: 15.1, 15.5. []
  4. 4.0 4.1 4.2 4.3 4.4 Kamata K, Mitsuya M, Nishimura T, Eiki J, Nagata Y. Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase. Structure. 2004 Mar;12(3):429-38. PMID:15016359 doi:10.1016/j.str.2004.02.005
  5. Postic C, Shiota M, Magnuson MA. Cell-specific roles of glucokinase in glucose homeostasis. Recent Prog Horm Res. 2001;56:195-217. PMID:11237213

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Kyle Schroering, Ann Taylor, Michal Harel, Drew McCaffrey, Alexander Berchansky, Cody Leatherman, David Canner

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